围绝经期妇女血清维生素D水平与骨质疏松的相关性研究

目的：探讨深圳市龙岗地区围绝经期妇女维生素D水平与骨质疏松的关系。方法收集2012年8月至2013年8月参加体检的围绝经期妇女血清，采用串联质谱法检测血清维生素D、维生素D2及维生素D3水平，并使用双能X线吸收仪（DEXA）测定髋部及L1～4的骨密度。结果435例受试者中，血清维生素D水平缺乏情况普遍存在，且以维生素D3缺乏为主；严重缺乏组左侧股骨颈骨密度为（0．623±0．087）g/cm^2，明显低于维生素D不足组的（0．726±0．091）g/cm^2及充足组的（0．731±0．089）g/cm^2（P＜0．05）；wards三角骨密度为（0．391±0．054）g/cm^2，明显低于维生素D不足组的（0．492±0．061）g/cm^2及充足组的（0．524±0．075）g/cm^2，3个年龄组的左侧股骨颈、wards三角、L1～4、大粗隆、大转子区及左侧股骨上端骨密度均随着年龄增大而逐渐降低，差异有统计学意义（P＜0．05）。结论深圳龙岗地区围绝经期妇女普遍缺乏维生素D，需要加强宣教，低维生素D水平与骨骼中某些部位的低骨密度相关。

Relationship between serum level of vitamin D and osteoporosis in postmenopausal women

Objective To explore the relationship between serum level of vitamin D and osteoporosis in postm-enopausal women in this region .Methods A total of 435 postmenopausal women ,receiving physical examination from August 2012 to August 2013 were enrolled .Serum levels of total vitamin D ,vitamin D2 and vitamin D3 were de-tected by using tandem mass spectrometry ,and bone density of hip and L1-4 were detected by using dual energy X-ray absorptiometry（DEXA） procedure measuring .Results In all subjects ,insufficiency of vitamin D was ubiquitous , mainly of which was insufficiency of vitamin D3 .The bone density of left femoral neck in severely deficient group was （0 .623 ± 0 .087）g/cm^2 ,significantly lower than the（0 .726 ± 0 .091） and（0 .731 ± 0 .089） g/cm^2 of insufficient group and sufficient group（P〈0 .05） .The wards triangular bone density in severely deficient group was （0 .391 ± 0 .054） g/cm^2 ,significantly lower than the（0 .492 ± 0 .061） and（0 .524 ± 0 .075）g/cm^2 of insufficient group and sufficient group .Bone density of left femoral neck ,wards triangle ,L1-4 ,greater trochanter ,trochanter region and left proximal femur were decreased gradually with the increasing of age （P〈 0 .01） .Conclusion The insufficiency of vitamin D could be ubiquitous in postmenopausal women in this area .Health education should be strengthened .Low levels of vi-tamin D might be correlated with the deceasing of bone density .