自噬在类风湿关节炎中的作用及中药干预研究进展

类风湿关节炎(RA)目前临床上多使用糖皮质激素或免疫抑制剂进行治疗,但长期使用具有明显的毒副作用,且免疫抑制剂价格昂贵,一定程度限制其广泛的应用。中药治疗RA历史悠久,且毒副作用小,但其具体作用机制不甚明确。自噬的过程是细胞自身在受到外界的刺激,通过细胞内信号转导,触发的一系列细胞维持内环境稳定的一种主动的生物学过程,其异常参与多种疾病的发生。目前研究表明自噬异常与RA的发生发展过程关系密切,可以干预RA血管翳生成、滑膜炎症和骨破坏等关键病理环节,从而影响RA的进展和预后。近年来很多研究发现中药复方及其活性成分可以通过调节自噬过程,发挥治疗RA的作用。本文对中药调控自噬进而干预RA的相关文献进行调研,以期为中药治疗RA重要作用机制、新药开发及临床治疗提供新思路。

Research Progress of Role of Autophagy in Rheumatoid Arthritis and Traditional Chinese Medicine Intervention

For rheumatoid arthritis,glucocorticoids or immunosuppressive agents are currently used in clinical treatment,but long-term use of these drugs has large side effect on humans,and immunosuppressive agents are expensive.To a certain extent,its wide application is limited.The treatment of rheumatoid arthritis with traditional Chinese medicine(TCM)has a long history and little toxic and side effect,but its specific mechanism of action needs further exploration.The process of autophagy is an active biological process in which cells themselves are stimulated by the outside world through intracellular signal transduction to maintain a stable internal environment.Its abnormality is involved in the occurrence of many diseases.At present,studies have shown that abnormal autophagy is closely related to the occurrence and development of rheumatoid arthritis,which can interfere with the pathological changes of RA pannus formation,synovial inflammation and bone destruction and affect the disease process.In recent years,many studies have found that traditional Chinese medicine and its active ingredients can affect the pathological development of rheumatoid arthritis by regulating autophagy.This article investigates the relevant literature on the intervention of rheumatoid arthritis by regulating autophagy through using TCM,with a view to providing new ideas for basic research,new drug development and clinical treatment of rheumatoid arthritis.