| β-FIBRINOGEN PROMOTER-455 G／A （HaeⅢ） POLYMORPHISM PREDICTION OF PLASMA FIBRINOGEN BUT NOT OF ISCHEMIC CEREBROVASCULAR DISEASE |
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| 引用本文： | 毕胜 王德生 李国忠 温世荣 潘尚哈. β-FIBRINOGEN PROMOTER-455 G／A （HaeⅢ） POLYMORPHISM PREDICTION OF PLASMA FIBRINOGEN BUT NOT OF ISCHEMIC CEREBROVASCULAR DISEASE[J]. 中国医学科学杂志(英文版), 2004, 19(1): 1-5 |
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| 作者姓名： | 毕胜 王德生 李国忠 温世荣 潘尚哈 |
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| 作者单位： | [1]InstituteofCerebrovascularDiseasesandRelatedDisorders,DepartmentofNeurology,theFirstClinicalCollegeofHarbinMedicalUniversity,Harbin150001 [2]InstituteofCerebrovascularDiseasesandRelatedDisorders,CentralLaboratory,theFirstClinicalCollegeofHarbinMedicalUniversity,Harbin150001 |
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| 摘 要： | Objective The-455 G/A (HaeⅢ) polymorphism of β-fibrinogen gene influences levels of plasma fibrinogen. We further investigated whether it influences the risk of isehemie cerebrovaseular disease. Methods We accumulated 134 acute isehemic eerebrovaseular disease (ICVD) eases and compared their -455 G/A status with a control group (n=166). The β-fibrinogen gene -455 G/A polymorphism was analyzed for all subjects by PCR-RFLP with the restrictive enzyme HaeⅢ. Results Plasma fibrinogen was higher in AA homozygous participants (341mg/dL) than in participants carrying the G allele: GA (290mg/dL), GG (298mg/dL) in the control group. Plasma fibrinogen was also higher in AA homozygous patients (353mg/dL) than in eases carrying the G allele: GA (287mg/dL), GG (302mg/dL) in the ICVD group. However, there was no significant association between β-fibrinogen gene -455 G/A polymorphism and ICVD group. Conclusions Although a small effect cannot be excluded, β-fibrinogen gene -455 G/A polymorphism is an independent predictor of plasma fibrinogen, but not of isehemie cerebrovaacular disease.
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| 关 键 词： | β-纤维蛋白原促进剂 基因多态性 血浆 缺血性脑血管病 临床意义 RT-PCR |
Beta-fibrinogen promoter -455 G/A (HaeIII) polymorphism prediction of plasma fibrinogen but not of ischemic cerebrovascular disease. |
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| Sheng Bi,Desheng Wang,Guozhong Li,Shirong Wen,Shangha Pan. Beta-fibrinogen promoter -455 G/A (HaeIII) polymorphism prediction of plasma fibrinogen but not of ischemic cerebrovascular disease.[J]. Chinese medical sciences journal, 2004, 19(1): 1-5 |
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| Authors: | Sheng Bi Desheng Wang Guozhong Li Shirong Wen Shangha Pan |
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| Affiliation: | Institute of Cerebrovascular Diseases and Related Disorders, Department of Neurology, First Clinical College of Harbin Medical University, Harbin 150001. bisheng98@hotmail.com |
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| Abstract: | OBJECTIVE: The -455 G/A (HaeIII) polymorphism of beta-fibrinogen gene influences levels of plasma fibrinogen. We further investigated whether it influences the risk of ischemic cerebrovascular disease. METHODS: We accumulated 134 acute ischemic cerebrovascular disease (ICVD) cases and compared their -455 G/A status with a control group (n = 166). The beta-fibrinogen gene -455 G/A polymorphism was analyzed for all subjects by PCR-RFLP with the restrictive enzyme HaeIII. RESULTS: Plasma fibrinogen was higher in AA homozygous participants (341 mg/dL) than in participants carrying the G allele: GA (290 mg/dL), GG (298 mg/dL) in the control group. Plasma fibrinogen was also higher in AA homozygous patients (353 mg/dL) than in cases carrying the G allele: GA (287 mg/dL), GG (302 mg/dL) in the ICVD group. However, there was no significant association between beta-fibrinogen gene -455 G/A polymorphism and ICVD group. CONCLUSIONS: Although a small effect cannot be excluded, beta-fibrinogen gene -455 G/A polymorphism is an independent predictor of plasma fibrinogen, but not of ischemic cerebrovascular disease. |
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