载脂蛋白E基因多态性与中国人阿尔茨海默病和颈动脉粥样硬化相关性研究

为了探讨中国散发性阿尔茨海默病（SAD)颈动脉粥样硬化（CAS）与ApoE基因多态性的关系，应用聚合酶链式反应－限制性片段长度多态性（PCR－RFLP）技术检测46名SAD患者、31名CAS患者及50名正常老年人的ApoE基因多态性分布特征。结果显示SAD组及CAS组ApoE ε4等位基因频率均高于对照组（P＜0．05）；SAD组为15．2％，CAS组为14．5％，对照组为3．0％，但CAS组ApoEε2等位基因频率明显高于SAD组（P＜0．05）；CAS组为41．9％，SAD组为21．7％本研究提示，ApoE4等位基因是SAD和CAS的共同危险因素，但ApoE2等位基因对CAS病人患AD具有保护作用。

Association between ApoEgene polymorphism and Alzheimer

To investigate the relationship between apoE gene polymorphism and sporadic Alzheimers disease（SAD） and Carotic arteriosclerosis (CAS). ApoE gene distribution was determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique in 46 SAD, 31 CAS and 50 normal controls. The ApoE 4 allele frequency was increased in both SAD and CAS as compared to controls. While the ApoE 2 allele frequency was much higher in CAS as compared to SAD. The ApoE 4 allele of ApoE gene may be risk factors for both SAD and CAS in Chinese, while the ApoE 2 allele genes may protect CAS individuals from SAD.