| 2,3-二甲基-2-异丙基-丁酸的合成 |
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| 引用本文： | 张弦,王建新,武建利,孙培冬.2,3-二甲基-2-异丙基-丁酸的合成[J].合成化学,2009,17(6). |
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| 作者姓名： | 张弦 王建新 武建利 孙培冬 |
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| 作者单位： | 江南大学,化学与材料工程学院,江苏,无锡,214122 |
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| 摘 要： | 二异丙基酮与MeMgBr反应制备2,3,4-三甲基-3-戊醇;再经Koch-Haaf羧化反应合成了2,3-二甲基-2-异丙基-丁酸,总收率51%,其结构经NMR,IR和GC-MS确证.
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| 关 键 词： | 二异丙基酮 2 3-二甲基-2-异丙基-丁酸 羧化反应 合成 |
Synthesis of 2-Isopropyl-2,3-dimethyl-butyric Acid |
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| ZHANG Xuan,WANG Jian-xin,WU Jian-li,SUN Pei-dong.Synthesis of 2-Isopropyl-2,3-dimethyl-butyric Acid[J].Chinese Journal of Synthetic Chemistry,2009,17(6). |
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| Authors: | ZHANG Xuan WANG Jian-xin WU Jian-li SUN Pei-dong |
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| Abstract: | 2-Isopropyl-2,3-dimethyl-butyric acid in total yield of 51% was synthesized by the reaction of diisopropyl ketone with Grignard reagent of bromomethane(MeMgBr) to obtain 2,3,4-trimethyl-3-pentanol, and then by Koch-Haaf carboxylation. The structure was confirmed by NMR, IR and GC-MS. |
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| Keywords: | diisopropyl ketone 2-isopropyl-2 3-dimethyl-butyric acid carboxylation synthesis |
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