恶性胶质瘤外照射加X-刀推量的治疗模式的探讨

背景与目的:恶性胶质瘤是预后极差的常见颅内恶性肿瘤,治愈很困难。本研究报告恶性胶质瘤外照射加X刀推量的治疗模式的疗效。方法:对15例确诊为恶性胶质瘤的患者进行了外照射加X-刀推量的治疗。外照射50Gy/25F/5W后,紧接着用X-刀推量7～10Gy。结果:治疗后近期效果满意,无严重神经功能障碍并发症。3例患者分别死于X刀后4、5、11个月,余均健在。全组仅1例在疗后3个月出现脑水肿,给以对症治疗后缓解。余患者无严重的放射反应。结论:恶性胶质瘤外照射加X-刀推量的治疗模式是可行的。

Stereotactic Radiosurgery Following Conventional Radiotherapy for Patients with Malignant Glioma

BACKGROUND & OBJECTIVE: Glioma is the commonest malignant primary brain tumor with poor prognosis. We reported the effect of stereotactic radiosurgery (SRS) following conventional external beam radiation therapy (EBRT) on the patients with malignant glioma. METHODS: A total of 15 patients with malignant glioma were treated to SRS following EBRT (50Gy/25F/5W). The dose of radiosurgery ranged from 7 Gy to 10 Gy. RESULTS: The short term effect was satisfactory. There was no complication of neurological deficit. Three patients died in 4 month, 5 month and 11month after radiosurgery. Brain edema occurred in 1case three months after X-knife and this was relieved through medical treatment. There was no serious radiation reaction reported. CONCLUSIONS: Stereotactic radiosurgery (SRS) following to conventional external beam radiation therapy (EBRT) is feasible in treatment of malignant glioma.