Electrochemical Behavior and Determination of Hyoscine‐N‐Butylbromide from Pharmaceutical Preparations

The electrooxidation of hyoscine N‐butylbromide (HBB) was investigated by rotating disk electrode voltammetry, cyclic voltammetry and controlled potential coulometry in 0.1 M HNO₃ and in 0.1 M tetrabutylammonium perchlorate (TBAP) solutions of acetonitrile at a platinum (Pt) electrode. Based on the results obtained, it is suggested that a bromide ion of HBB was oxidized in one reversible step in aqueous solutions and in two reversible steps in acetonitrile. A differential pulse voltammetric (DPV) method at a Pt electrode was developed for the determination of HBB in the concentration range of 1.0 × 10^?6‐1.0 × 10^?3 M. The procedure was applied to the determination of HBB in its formulations as well as its recovery from blood serum and urine samples.