| 变应性疾病患儿皮肤变应原试验与血清尘螨特异性IgE及IgG4水平的关系 |
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| 引用本文： | 谢庆玲,甄宏,胡琼燕,谭颖,温志红,李柳青,梁珍花. 变应性疾病患儿皮肤变应原试验与血清尘螨特异性IgE及IgG4水平的关系[J]. 实用儿科临床杂志, 2010, 0(4) |
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| 作者姓名： | 谢庆玲 甄宏 胡琼燕 谭颖 温志红 李柳青 梁珍花 |
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| 作者单位： | 广西壮族自治区人民医院儿科; |
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| 基金项目： | 广西医疗卫生重点科研课题(重200734) |
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| 摘 要： | 目的探讨变应性疾病(包括支气管哮喘和变应性鼻炎)患儿常见的变应原与血清尘螨特异性IgE(sIgE)和IgG4水平的关系。方法对310例4～13岁变应性疾病儿童进行12种常见变应原皮肤点刺试验,同期采用夹心ELISA方法检测血清尘螨sIgE和IgG4水平。采用SPSS13.0软件进行统计学分析。结果变应性疾病儿童皮肤变应原检测阳性100%(310/310例),≥3种变应原阳性者占35.8%(111/310例)。引起变应性疾病的变应原主要为吸入物,阳性率最高的变应原是粉尘螨。变应性疾病儿童血清尘螨sIgE和IgG4水平明显高于健康对照组(t=14.253、12.314,Pa<0.01)。血清尘螨sIgE水平与皮肤变应原试验阳性种类的多少无相关性(r=-0.004 3,P>0.05);粉尘螨变应原阳性强度与血清尘螨sIgE水平呈正相关(r=0.219 8,P<0.05);血清尘螨sIgE水平与IgG4水平呈一定正相关(r=0.173 0,P<0.05)。结论变应原皮肤点刺试验有助于发现变应性疾病儿童的变应原及了解机体免疫状态强度,提供应尽可能避免接触的变应原,有条件者可进行脱敏治疗。监测血清sIgE和IgG4水平对...
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| 关 键 词： | 哮喘 变应性鼻炎 变应原 皮肤点刺试验 特异性免疫球蛋白E 免疫球蛋白G4 |
Relationships of Skin Test of Allergens and Serum Dermatophagoides Farina Specific IgE and IgG4 Levels in Children with Allergic Disease |
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| Abstract: | Objective To explore the relationships of the common allergen and the concentration of serum dermatophagoides farina specific IgE(sIgE) and IgG4 in allergic children with asthma and/or allergic rhinitis.Methods Three hundred and ten cases of children with asthma and/or allergic rhinitis were involved in the study,and skin prick tests with 12 common allergens including dermatophagoides were taken in children and the concentrations of serum dermatophagoides farina sIgE and IgG4 were measured with the ELISA me... |
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| Keywords: | asthma allergic rhinitis allergens skin prick test specific immunoglobulin E immunoglobulin G4 |
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