| NOD2基因与原发性肝癌 |
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| 引用本文： | 梁宁,乔丽丽,谢健,张建东. NOD2基因与原发性肝癌[J]. 国外医学(肿瘤学分册), 2013, 0(12): 927-929 |
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| 作者姓名： | 梁宁 乔丽丽 谢健 张建东 |
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| 作者单位： | [1]潍坊医学院研究生院,261061 [2]山东大学医学院研究生院 ,261061 [3]山东大学附属千佛山医院肿瘤放疗科,261061 |
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| 基金项目： | 山东省自然科学基金（ZR2012HM095） |
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| 摘 要： | 核苷酸结合寡聚化结构域蛋白2（NOD2）可通过识别细菌细胞壁的肽聚糖及其裂解产物胞壁酰二肽，参与宿主对病原体的免疫应答，参与调节自然免疫和特异性免疫。NOD2作为一种新发现的细胞内模式识别受体，可通过基因变异、诱发肝脏炎症反应、激活相应信号通路在原发性肝癌的发生发展中发挥重要作用。
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| 关 键 词： | 多态性 单核苷酸 癌 肝细胞 核苷酸结合寡聚化结构域蛋白2 |
NOD2 gene and primary hepatocellular carcinoma |
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| Affiliation: | LIANG Ning , QIAO Li-li, XIE Jian, ZHANG Jiaa- dong. Graduate School of Weifang Medical College, Weifang 261061, China |
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| Abstract: | Nucleotide-binding oligomerization domain protein 2 （NOD2） involves in host immune responses to pathogens and regulates natural immunity and specific immunity by identifying the peptidoglycan of bacterial cell walls and cleavage product muramyl dipeptide. As a newly discovered intraeellular pattern recog- nition receptor, NOD2 plays important roles in the development of primary hepatocellular carcinoma by gene mutate, inducing liver inflammatory reaction and activating relevant signaling pathways. |
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| Keywords: | Polymorphism, single nucleotide Carcinoma, hepatocellular Nucleotide-binding oligomerization domain protein 2 |
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