同型半胱氨酸检测与临床应用

目的通过检测血浆同型半胱氨酸（Hcy）浓度,探讨Hcy与心脑血管疾病及2型糖尿病早期肾损害的关系。方法选择40～70岁的心脑血管疾病及2型糖尿病住院患者265例,健康体检健康者52例,用RocheP800全自动生化分析仪测定血浆中Hcy浓度。结果心血管病组、脑血管病组、糖尿病B组血浆Hcy水平均显著高于健康对照组（P〈0.05）,糖尿病A组虽高于健康对照组,但是差异无统计学意义。结论高Hcy血症与心血管疾病密切相关,是心血管疾病发病的一个重要危险因子;脑血管疾病与血浆Hcy呈正相关;血浆Hcy浓度随糖尿病肾病的发生及发展逐渐升高。

Plasma homocysteine testing and clinical application

Objective To investigate the relationship of plasma homocysteine（hcy） with cardiovascular or cerebrovascular diseases and early renal damage of type 2 diabetes mellitus by detection of plasma homoncysteine.Methods 265 patients aged 4o to 70 with Cardiovascular or cerebrovascular disease and type 2 diabetes mellitus kidney disease as well as 52 cases with physical examination were selected for detecting levels of plasma homocystine by Roche p800.Results After statistical analysis,plasma Hcy levels of cardiovascular disease group,cerebrovascular disease group and type 2 diabetes mellitus kidney disease B group were significantly higher than physical examination group（P0.05）.There were no significant difference between Plasma hcy level of type 2 diabetes mellitus kidney disease A group and physical examination group.Conclusion High Hcy level is closely correlated with cardiovascular diseases,it is also an important risk factor.Plasma levels of Hcy are positively correlated with cerebral vascular disease,the concentration of plasma Hcy gradually increases with the occurrence and development of diabetic nephropathy.