载脂蛋白E基因多态性与2型糖尿病合并脑梗死的关系

目的研究载脂蛋白E（ApoE）基因多态性与2型糖尿病（T2DM）血脂及其脑梗死并发症的关系。方法选择136例山东汉族T2DM患者为T2DM组，其中64例合并脑梗死（ACI）者为T2DM合并ACI组、72例未合并ACI者为T2DM未合并ACI组；60例健康对照者为对照组，应用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法检测其ApoE基因多态性，并探讨ApoE 基因多态性与血脂异常和脑梗死并发症的关系。结果① T2DM组与健康对照组间基因型与等位基因分布频率均无统计学意义；② T2DM患者中总胆固醇、低密度脂蛋白水平在等位基因∈4组最高，在∈2组最低，差异具有统计学意义（P＜0.01）；③ T2DM合并脑梗死患者中∈4组11例，与无脑梗死糖尿病患者中∈4组4例相比，差异具有统计学意义（χ²=4.672，P＜0.05）。结论ApoE∈4等位基因与高脂血症有关，且∈4等位基因可能是T2DM合并脑梗死的危险因子。

Relationship between apolipoprotein E gene polymorphism and type 2 diabetes mellitus with arteriosclerotic cerebral infarction

To explore the relationship between apolipoprotein E (ApoE) gene polymorphism and dyslipidemia as well as arteriosclerotic cerebral infarction (ACI )in type 2 diabetic patients. Methods136 patients with type 2 diabetes mellitus, 64 patients with ACI and 72 patients without ACI, and 60 healthy controls were determined for the ApoE gene polymorphism by PCR RFLP. Results① Differences of distribution frequency in genotype and allelomorphic gene between type 2 diabetic patients and controls were insignificant. ② The TC and LDL c levels in group ∈4 were the highest while the lowest were in group ∈2 (P＜0.01). ③ 11 cases of the ∈4 allelle were found in the type 2 diabetic group with ACI and 4 were found in the type 2 diabetic group without ACI (χ2=4.672，P＜0.05). ConclusionThe ApoE ∈4 allele is related to hyperlipoidemia and the ∈4 allele is possibly a risk factor of type 2 diabetes mellitus.