Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2

Authors:	Aleksunes Lauren M Slitt Angela L Maher Jonathan M Augustine Lisa M Goedken Michael J Chan Jefferson Y Cherrington Nathan J Klaassen Curtis D Manautou José E

Affiliation:	Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, 69 North Eagleville Road, Unit 3092, Storrs, CT 06269-3092, USA. laleksunes@kumc.edu

Abstract:

Keywords:	APAP, acetaminophen ALT, alanine aminotransferase AREs, antioxidant response elements Abcc, ATP-binding cassette, subfamily c bDNA, branched DNA signal amplification DAPI, 4′,6-diamidino-2-phenylindole Gclc, glutamate cysteine ligase catalytic Gclm, glutamate cysteine ligase modifier GSH, glutathione Ho-1, heme oxygenase-1 Keap1, Kelch-like ECH-associated protein 1 Mrps, multidrug resistance-associated proteins Nqo1, NAD(P)H:quinone oxidoreductase 1 NAPQI, N-acetyl-p-benzoquinone imine Nrf2, nuclear factor-E2-related factor 2 PBS-T, PBS-Triton X-100 RLU, relative light units Ugt, UDP-glucuronosyltransferase WT, wild-type.
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