| 八肽胆囊收缩素对大鼠胃平滑肌细胞收缩活动的作用 |
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| 引用本文： | 王文颖 周吕. 八肽胆囊收缩素对大鼠胃平滑肌细胞收缩活动的作用[J]. 基础医学与临床, 1996, 16(1): 44-48 |
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| 作者姓名： | 王文颖 周吕 |
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| 作者单位： | 中国医学科学院中国协和医科大学基础医学研究所生理研究室 |
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| 基金项目： | 国家自然科学基金,卫生部科研基金 |
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| 摘 要： | 通过游离平滑肌细胞的制备，观察ＣＣＫ－８对大鼠胃体，胃窦和幽门平滑肌细胞的直接作用并初步探讨其作用机制，结果表明：１．ＣＣＫ－８通过结合特异的受体在而发挥对胃窦，幽门平滑肌细胞的收缩作用和对胃体平滑肌细胞的舒张作用。２．ＣＣＫ－８引起胃窦，幽门有细胞收缩性过程中，胞内Ｃａ＾２＋释放可能起重作用，而ＣＣＫ－８引起胃体肌细胞舒张则可能与胞浆，ｃＡＭＰ浓度的改变有关系。
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| 关 键 词： | 胃 平滑肌细胞 胆囊收缩素 受体 收缩 |
Contracting EHect of CCK-8 on Isolated Gastric Smooth Muscle Cells in Rats |
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| Wang Wenying,Zhou Lu. Contracting EHect of CCK-8 on Isolated Gastric Smooth Muscle Cells in Rats[J]. Basic Medical Sciences and Clinics, 1996, 16(1): 44-48 |
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| Authors: | Wang Wenying Zhou Lu |
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| Affiliation: | Department of physiology.Institute of Basic Medical Sciences.Chinese Academy of Medical Sciences and PUMC.Beijing 100005 |
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| Abstract: | he isolated gastric body.antrum and pylorus smooth muscle cells were used to investigate direct contractingeffect of CCK-8 on gastric smooth muscle cells.The results showed.(1)The contracting effect of CCK-8 on theantrum and pylorus smooth muscle cells and the relaxing effect on the gastric body muscle cells were exerted bybinding to specific CCK receptors.(2)During the contracting process.intracellular calcium may play a major rolewhile the cAMP concentration changes may be related to the relaxation of the body cells. |
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| Keywords: | gastric smcoth muscle cells CCL-8 contraction receptor |
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