| 心包腔内注入重组改构人肿瘤坏死因子治疗恶性心包积液的疗效分析 |
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| 引用本文： | Kaijian Lei,Hua Luo,Yuming Jia,Shengqun Ying.心包腔内注入重组改构人肿瘤坏死因子治疗恶性心包积液的疗效分析[J].中德临床肿瘤学杂志,2007,6(5):442-443. |
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| 作者姓名： | Kaijian Lei Hua Luo Yuming Jia Shengqun Ying |
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| 作者单位： | Kaijian Lei，Hua Luo，Yuming Jia，Shengqun Ying Department of Oncology，The No. 2 People’s Hospital of Yibin，Yibin 644000，China |
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| 摘 要： | Objective: To evaluate the therapeutic efficacy of injecting recombinant mutant human tumor necrosis factor (rmhTNF) into pericardial cavity of carcinoma patients with malignant pericardial effusion. Methods: In 20 cases of malignant pericardial effusion, the intrapericardial catheter was inserted into pericardial cavity, and then rmhTNF of 1.5 × 107 U was infused. The infusion was repeated every 5-7 days with the total 4-6 times. If the effusion disappeared, rmhTNF was then used 2 more times and then the intrapericardial catheter was pulled out. Results: Of 20 patients, 14 were complete response (CR), 4 were partial response (PR) and 2 no change (NC). The disappearance of effusion in 6 cases lasted for more than 6 months. Conclusion: Injecting rmhTNF into pericardial cavity may be a better way to control malignant pericardial effusion and has mild side effects.
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| 关 键 词： | 心包腔 肿瘤坏死因子 治疗 恶性心包积液 |
| 收稿时间： | 19 April 2007 |
| 修稿时间： | 2007-04-19 |
Controlling malignant pericardial effusion by intrapericardial administration of recombinant mutant human tumor necrosis factor in patients with carcinoma |
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| Kaijian Lei,Hua Luo,Yuming Jia,Shengqun Ying.Controlling malignant pericardial effusion by intrapericardial administration of recombinant mutant human tumor necrosis factor in patients with carcinoma[J].The Chinese-German Journal of Clinical Oncology,2007,6(5):442-443. |
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| Authors: | Kaijian Lei Hua Luo Yuming Jia Shengqun Ying |
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| Affiliation: | (1) Department of Oncology, The No. 2 People’s Hospital of Yibin, Yibin, 644000, China |
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| Abstract: | Objective: To evaluate the therapeutic efficacy of injecting recombinant mutant human tumor necrosis factor (rmhTNF) into pericardial cavity of carcinoma patients with malignant pericardial effusion. Methods: In 20 cases of malignant pericardial effusion, the intrapericardial catheter was inserted into pericardial cavity, and then rmhTNF of 1.5 × 107 U was infused. The infusion was repeated every 5-7 days with the total 4-6 times. If the effusion disappeared, rmhTNF was then used 2 more times and then the intrapericardial catheter was pulled out. Results: Of 20 patients, 14 were complete response (CR), 4 were partial response (PR) and 2 no change (NC). The disappearance of effusion in 6 cases lasted for more than 6months. Conclusion: Injecting rmhTNF into pericardial cavity may be a better way to control malignant pericardial effusion and has mild side effects. |
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| Keywords: | pericardial effusion recombinant mutant human tumor necrosis factor (rmhTNF) intrapericardial catheter |
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