| 嘧菌酯的合成 |
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| 引用本文： | 董捷,廖道华,楼江松,皮红军.嘧菌酯的合成[J].精细化工中间体,2007,37(2):25-27. |
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| 作者姓名： | 董捷 廖道华 楼江松 皮红军 |
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| 作者单位： | 华东理工大学,药学院,上海,200237 |
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| 摘 要： | 报道了合成高效杀菌剂嘧菌酯(1)的方法。首先以邻羟基苯乙酸(2)为原料与原甲酸三甲酯在醋酐中反应制备3-(α-甲氧基)-亚甲基苯并呋喃-2(3氢)-酮(4),收率59%;化合物4再与甲醇钠、4,6-二氯嘧啶在四氢呋喃中反应得到(E)-2-2-(6-氯嘧啶-4-基氧基)苯基]-3-甲氧基丙烯酸甲酯(6),收率60%;化合物6与水杨腈反应得到嘧菌酯(1),收率81%。总收率28.6%。
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| 关 键 词： | 杀菌剂 嘧菌酯 邻羟基苯乙酸 4 6-二氯嘧啶 水杨腈 |
| 文章编号： | 1009-9212（2007）02-0025-03 |
| 修稿时间： | 2006-12-27 |
Synthesis of Azoxystrobin |
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| DONG Jie,LIAO Dao-hua,LOU Jiang-song,PI Hong-jun.Synthesis of Azoxystrobin[J].Fine Chemical Intermediates,2007,37(2):25-27. |
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| Authors: | DONG Jie LIAO Dao-hua LOU Jiang-song PI Hong-jun |
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| Affiliation: | School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China |
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| Abstract: | Azoxystrobin,methyl(E)-2-｛2-6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl｝-3-methoxyacrylate (1),is a new fungicide of methoxyacrylates. A new practical synthesis of azoxystrobin was described in this paper. 2-Hydroxyphenylacetic(2)was treated with trimethyl orthoformate and acetic anhydride to form 3-(-methoxy)-methylenebenzo-furan-2(3H)-one(4),the yield is 59%. The compound 4 then reacted with sodium methoxide,methanol and 4,6-dichloropyrimidine in tetrahydrofuran to produce methyl(E)-2-2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxyacrylate(6),the yield is 60%. Then the compound 4 was treated with 2-cyanophenol to form azoxystrobin,and the yield is 81%. The total yield of the product is 28.6%. |
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| Keywords: | fungicide azoxystrobin 2-hydroxyphenylacetic 4 6-dichloropyrimidine 2-cyanophenol |
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