网织血小板在系统性红斑狼疮患者的临床应用

目的：研究系统性红斑狼疮（SLE）患者合并血小板减少疾病的发病机制，探讨网织血小板（RP）在诊疗SLE合并血小板减少疾病中的临床应用价值。方法确诊为SLE患者55例和健康体检者50例，对SLE伴血小板减少的患者进行治疗前后检查，采用Sysmex XE-5000全自动血细胞分析仪检测网织血小板百分比（IPF）以及其他外周血细胞参数。结果 SLE患者组和正常对照组的IPF检测结果分别为（5．30＆#177;3．75）％、（2．74＆#177;1．05）％，两者比较差异有统计学意义（P＜0．05）；SLE伴血小板减少组的IPF（10．14＆#177;3．66）％]、血小板计数（PLT）（67．2＆#177;13．5）＆#215;109/L]、血小板平均体积（MPV）（12．64＆#177;0．92）fL]、血小板分布宽度（PDW）（18．24＆#177;1．70）fL]与正常对照组、SLE血小板未减少组比较，差异均有统计学意义（P＜0．05）；SLE伴血小板减少组治疗前后的IPF分别为（9．76＆#177;1．82）％和（5．86＆#177;0．96）％，两者比较差异有统计学意义（P＜0．05）。结论 SLE患者血小板减少的主要原因可能与外周血小板破坏有关，IPF的高低可以出反映骨髓血小板的生成情况，有助于疾病的辅助诊断和预后判断。

The application of reticulated platelet counts in the systemic lupus erythematosus patients with thrombocytopenia

Objective To study the disease pathogenesis of systemic lupus erythematosus patients with thrombocytopenia ,and discuss reticulated platelets （RP） in SLE merger thrombocytopenia disease of diagnosis and treatment in the clinical application val-ue .Methods 55 patients diagnosed with SLE patients and 50 cases of healthy check-up ,low platelet count patients of SLE patients treated before and after the inspection by Sysmex XE-5000 automatic blood cell analyzer immature platelet fraction （IPF） and other peripheral blood cell parameters .Results Group of patients with SLE and normal controls of IPF test results respectively was （5 .30 ＆#177; 3 .75）% ,（2 .74 ＆#177; 1 .05）% ,both comparative difference was statistically significant （P＆lt;0 .05）;SLE associated with throm-bocytopeniagroupofIPF（10.14＆#177;3.66）% ],platelets（PLT）（67.2＆#177;13.5）＆#215;109/L],meanplateletvolume（MPV）（12.64＆#177; 0 .92）fL] ,platelet distribution width（PDW）（18 .24 ＆#177; 1 .70）fL] compared with normal control group and SLE did not reduce plate-let group ,differences had statistical significance（P＆lt;0 .05）;SLE associated with thrombocytopenia in patients with IPF respectively before and after treatment was （9 .76 ＆#177; 1 .82）% and （5 .86 ＆#177; 0 .96）% ,both comparative difference was statistically significant （P＆lt;0 . 05） .Conclusion The main cause of SLE patients with thrombocytopenia may be associated with peripheral blood platelet destruc-tion ,IPF′s result can reflect the bone marrow platelet production ,Help in the auxiliary diagnosis of disease and prognosis judg-ment .