血清肿瘤标记物检测对脑膜癌病早期诊断的意义

目的探讨血清肿瘤标记物检测对脑膜癌病早期诊断的意义。方法对26例脑膜癌病患者分别检测血清肿瘤标记物CEA、CA199、CA125,将其阳性率与首次腰穿找到癌细胞的阳性率进行比较。结果CEA的阳性率为65.4%(17例),首次腰穿找到癌细胞的阳性率为26.9%(7例),两者相比差异有统计学意义(P<0.05)。联合检测CEA、CA199和CA125的总阳性率为88.5%(23例),与首次腰穿找到癌细胞的阳性率(26.9%)比较,差异有统计学意义(P<0.05)。CA199和CA125的阳性率分别为11.5%(3例)和23.1%(6例),与首次腰穿找到癌细胞的阳性率相比差异无统计学意义(P>0.05)。结论联合检测血清肿瘤标记物的阳性率高于腰穿找到癌细胞阳性率约3.2倍,其敏感性高于腰穿找癌细胞,可作为脑膜癌病筛查的重要手段。

The early diagnostic value of detection of the serum tumor markers in patients with meningeal carcinomatiosis

Objective To investigate the early diagnostic value of detection of the serum tumor markers in patients with meningeal carcinomatosis.Methods The serum tumor markers CEA,CA199 and CA125 in 26 patients with meningeal carcinomatosis were detected,and the positive rate was compared with the incidence of the cancer cell found in those patients who firstly received lumbar puncture.Results The positive rate of CEA was 65.4%(17/26),the positive rate of cancer cell found in first lumbar puncture was 26.9%(7/26),there was a significant difference between the two results(P<0.05).The total positive rate of CEA,CA199 and CA125 was 88.5%(23/26),the positive rate of cancer cell found in first lumbar puncture was 26.9%(7/26),there was a significant difference between the two results(P<0.05).Conclusion The sensitivity of detecting serum tumor markers is 3.2 times higher than the way of finding cancer cell by first lumbar puncture.Detecting the serum tumor marker is more simple and easier,which could be used as an important way to screen the meningeal carcinomatosis.