| 坤怡宁颗粒的制备工艺研究 |
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| 引用本文： | 王溶溶,陈丹菲,汤建成,潘建明. 坤怡宁颗粒的制备工艺研究[J]. 中国现代应用药学, 2011, 28(9): 850-853 |
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| 作者姓名： | 王溶溶 陈丹菲 汤建成 潘建明 |
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| 作者单位： | 浙江省中药研究所，杭州 310023;浙江省中药研究所，杭州 310023;浙江省中药研究所，杭州 310023;浙江省中药研究所，杭州 310023 |
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| 摘 要： | 目的研究坤怡宁颗粒的制备工艺。方法以出膏率和芍药苷总量为指标,正交试验法优选水提条件;以颗粒吸湿性、流动性和成型性为指标,筛选颗粒最佳辅料与配比。结果最佳提取工艺为药材加10倍量水,煎煮2次,每次1.5 h;制备坤怡宁颗粒的最优处方组成为：1份浸膏与1份辅料（乳糖：蔗糖粉：糊精=3：1：1）混合制粒。结论该制备工艺合理、简便、实用,质量稳定。
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| 关 键 词： | 坤怡宁颗粒 正交试验 工艺研究 |
| 收稿时间： | 2010-08-19 |
Study on the Preparation Technology of Kunyining Granule |
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| WANG Rongrong,CHEN Danfei,TANG Jiancheng and PAN Jianming. Study on the Preparation Technology of Kunyining Granule[J]. The Chinese Journal of Modern Applied Pharmacy, 2011, 28(9): 850-853 |
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| Authors: | WANG Rongrong CHEN Danfei TANG Jiancheng PAN Jianming |
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| Affiliation: | Zhejiang Institute of Chinese Materia Medica, Hangzhou 310023, China;Zhejiang Institute of Chinese Materia Medica, Hangzhou 310023, China;Zhejiang Institute of Chinese Materia Medica, Hangzhou 310023, China;Zhejiang Institute of Chinese Materia Medica, Hangzhou 310023, China |
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| Abstract: | OBJECTIVE To optimize the preparation process of Kunyining granule.METHODS With the paste-forming rate and total content of paeoniflorin as the indexes,the optimal water-extraction condition was screened by orthogonal design.With hydroscopicity,fluidity and formability as the indexes,the appropriate ratio of the excipient and the formula were selected.RESULTS The optimum water-extraction condition was as follows: 10-fold water,decoction for 2 times and 1.5 hour for each time.The optimal ratio of the excipie... |
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| Keywords: | Kunyining granule orthogonal design process research |
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