2型糖尿病患者血浆肌肉抑制素与C肽相关性分析

目的:测定2型糖尿病(Type 2 diabetes,T2D)患者血浆肌肉抑制素(Myostatin)和C肽含量的变化,探讨二者在T2D发病机制中的作用。方法:酶联免疫分析法检测42例T2D患者和20例健康体检者血浆肌肉抑制素的含量,化学发光法测定空腹C肽浓度,临床生化检测血浆中脂质、血糖和胰岛素含量。结果:与健康对照组比较,T2D患者空腹血糖、胰岛素、甘油三酯和收缩压水平显著增加(P<0.05)。T2D糖尿病患者血浆肌肉抑制素水平比健康对照组显著增加(46.22±13.78 pg/L vs 86.83±29.10 pg/L,P<0.01)。T2D患者血浆肌肉抑制素水平与血浆C肽呈显著负相关(r=-0.56,P<0.01)。结论:T2D患者血浆中肌肉抑制素水平升高,且与血浆C肽水平呈显著负相关。

Analysis of Correlation between Plasma Myostatin and C-peptide in Patients with Type 2 Diabetes Mellitus

Objective To investigate the correlation between plasma myostatin and C-peptide in patients with type 2 diabetes mellitus（ T2D）. Methods Forty-two patients with T2 D and twenty healthy volunteers were recruited in this study. The levels of plasma myostatin and fasting C-peptide were detected with ELISA and chemiluminescent,respectively. The plasma lipid,fasting plasma glucose（ FPG） and serum insulin were measured. Results Compared with healthy controls,the levels of FPG,serum insulin,triglyceride and systolic pressure were significantly higer in patients with T2D（ P〈0. 05）. The level of plasma myostatin in T2 D patients was obviously higher than that of healthy controls（ 46. 22 ± 13. 78 pg /L vs 86. 83 ± 29. 10 pg /L,P 〈0. 01）. The level of plasma myostatin was negatively correlated with C-peptide level（ r =-0. 56,P〈 0. 01）.Conclusion The level of plasma myostatin was upregulated in patients with T2 D,which was negatively correlated with the level of C-peptide.