| 微生态制剂对慢性肝衰竭患者肠道菌群、血浆内毒素及细胞因子的影响 |
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| 引用本文： | 黄培宁,邓有辉. 微生态制剂对慢性肝衰竭患者肠道菌群、血浆内毒素及细胞因子的影响[J]. 中华医院感染学杂志, 2011, 0(18): 3798-3800 |
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| 作者姓名： | 黄培宁 邓有辉 |
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| 作者单位： | 百色市人民医院消化内科,广西百色,533000 |
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| 摘 要： | 目的探讨微生态制剂对慢性肝衰竭患者肠道菌群、血浆内毒素及细胞因子的影响。方法慢性肝衰竭患者58例,随机分为治疗组和对照组,每组29例,对照组给予保肝、补充白蛋白及对症治疗,治疗组则在相同治疗基础上给予微生态制剂,分别在治疗前1d及治疗4周后检测2组患者肠道菌群及变化、血浆内毒素变化、血浆炎性细胞因子IL-6、IL-8及TNF-α的变化。结果 2组患者治疗前肠道菌群、内毒素、IL-1、IL-6、TNF-α均在相同水平,差异无统计学意义;对照组患者治疗前后均无明显变化;治疗组患者治疗后肠球菌属、双歧杆菌和乳杆菌属的菌落数,均较治疗前和对照组治疗后明显增加,酵母样真菌菌落数均较治疗前和对照组治疗后显著降低(P<0.05);治疗后治疗组内毒素(30.66±23.2)pg/ml、IL-1(93.3±11.4)ng/L、IL-6(70.4±12.8)ng/L、TNF-α(130.4±22.8)ng/L,水平较治疗前和对照组治疗后明显降低(P<0.05);血浆内毒素与IL-1、IL-6、TNF-α水平呈显著正相关(P<0.05)。结论微生态制剂可调整慢性肝衰竭患者肠道菌群失调,减少肠源性内毒素的产生,减轻血浆炎性细胞因子表达,从而减轻肠源性内毒素血症对肝脏的损害,可在临床应用。
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| 关 键 词： | 慢性肝衰竭 微生态制剂 肠道菌群 内毒素 细胞因子 |
Effects of probiotics on intestinal flora plasma endotoxin and cytokines in patients with chronic liver failure |
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| HUANG Pei-ning,DENG You-hui. Effects of probiotics on intestinal flora plasma endotoxin and cytokines in patients with chronic liver failure[J]. Chinese Journal of Nosocomiology, 2011, 0(18): 3798-3800 |
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| Authors: | HUANG Pei-ning DENG You-hui |
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| Affiliation: | (People′s Hospital of Baise City,Baise,Guangxi 533000,China) |
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| Abstract: | OBJECTIVE To investigate the effects of probiotics on the intestinal flora plasma endotoxin and cytokines in patients with chronic liver failure.METHODS A total of 58 chronic liver failure patients were randomly divided into treatment group and control group(n=29),control group received the liver protection,supplement of albumin and symptomatic treatment,the treatment group were given the same treatment on the basis of probiotics.1 day before treatment,respectively,and after 4 weeks of treatment,patients we... |
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| Keywords: | Chronic liver failure Probiotics Intestinal flora Endotoxin Cytokines |
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