AHNAK2蛋白在食管鳞癌中的表达及其临床意义

目的： 探讨AHNAK2蛋白在食管鳞状细胞癌中的表达情况及其对预后判断的意义。方法：应用组织微阵列免疫组织化学技术(TMA-IHC)研究129例食管鳞状细胞癌中AHNAK2蛋白的表达情况及其与临床病理指标之间的相关性。结果：AHNAK2蛋白在食管鳞癌组织中的表达率显著高于癌旁组织(P = 0.023)，不表达、弱表达、中度表达和强表达的肿瘤比例分别为24.8% (32/129)、28.7%(37/129)、17.0%(22/129)和29.5%(38/129)，且随着分化程度的升高，该蛋白的表达率也随之增高(P = 0.004)。Kaplan-Meier生存分析显示，AHNAK2蛋白表达阴性患者术后生存时间短于表达阳性的患者(P = 0.027)。通过多因素回归分析发现，AHNAK2蛋白是一个独立预后因素(P = 0.018，HR = 0.461，95% CI：0.243～0.877)。结论：AHNAK2蛋白在食管鳞癌中表达上调，且与分化程度相关，有可能作为食管鳞癌预后判断的分子标志物。

Expression and clinical relevance of AHNAK2 in esophageal squamous cell carcinoma

OBJECTIVE：This study aimed to evaluate the expression and prognostic significance of AHNAK2 protein in esophageal squamous cell carcinoma （ESCC）. METHODS：The alteration and clinical relevance of AHNAK2 protein levels were investigated in 129 ESCC cases by immunohistochemistry. RESULTS：The expression of AHNAK2 protein was up-regulated in some of ESCC tissues. Negative,weak,moderate and high expression of AHNAK2 were observed in 24.8% （32/129）,28.7% （37/129）,17.0% （22/129）,and 29.5% （38/129） of tumors,respectively. Positive expression of AHNAK2 was significantly correlated with tumor differentiation （P=0.004）. Kaplan-Meier survival curves showed that ESCC patients with negative expression of AHNAK2 had shorter overall survival time （P=0.027）. Cox regression analysis indicated that AHNAK2 protein expression was an independent prognostic factor （P=0.018,HR=0.461,95%CI：0.243-0.877）. CONCLUSION：AHNAK2 was overexpressed in ESCC tissues and correlated with tumor differentiation. AHNAK2 expression might contribute to the prognostic evaluation of patients with this disease.