乳腺癌患者血清Leptin和VEGF的表达

目的：研究瘦素（Leptin）、血管内皮生长因子（VEGF）在乳腺癌患者血清中的表达，探讨其在乳腺癌诊断中的意义。方法：选择乳腺癌患者36例，乳腺良性增生病变患者31例，另选56例健康女性作为对照。分别用放射免疫分析（RIA）和酶联免疫吸附试验（ELISA）测定这些患者术前血清Leptin、VEGF。结果：正常对照组与良性病变组、乳腺癌组Leptin存在明显差异，正常对照组与乳腺癌组，良性病变组与乳腺癌组VEGF存在明显差异。乳腺癌患者术前血清Leptin、VEGF含量与有无淋巴结转移具有相关性。结论：乳腺癌患者术前血清Leptin、VEGF可作为鉴别乳腺良恶性肿瘤有无转移的指标。

Determination of Serum Leptin and Vascular Endothelial Growth Factor (VEGF) Contents in Patients with Breast Cancer

Objective To investigate the serum expression of leptin and vascular endothelial growth factor(VEGF) in patients with breast cancer and assess its diagnostic significance.Methods Thirty-six patients with breast cancer and thirty-one patients with benign breast disorders entered this study.Serum concentration of leptin(with RIA) and VEGF(with ELISA) were determined in these patients before operation as well as in 56 controls.All the tested subjects were post-menopausal women.Results The difference between the leptin levels in the controls and patients with benign breast disorders was significantly;80 was the difference between the leptin levels in controls and patients with breast cancer.Significant difference also existed between the VEGF levels in controls and patients with cancer as well as between the levels in patietns with benign breast disease and patients with cancer.Also,the serum leptin and VEGF levels in the cancerous patients with axillary metastasis were significantly higher than those in patietns without metastasis.Conclusion Serum leptin and VEGF might be taken as diagnostic tumor markers for malignanay and metastasis in patients with breast cancer.