| 糖尿病视网膜病变与HLA—A、B和DRB1基因相关性的研究 |
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| 引用本文： | 杨宝成,王大明,高素青,邓志辉.糖尿病视网膜病变与HLA—A、B和DRB1基因相关性的研究[J].江西医学检验,2008(3):242-244. |
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| 作者姓名： | 杨宝成 王大明 高素青 邓志辉 |
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| 作者单位： | 深圳市血液中心; |
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| 基金项目： | 广东省科技厅科技计划项目(编号:63111) |
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| 摘 要： | 目的研究HLA—A、B和DRB1基因与糖尿病视网膜病变的相关性。方法收集48名临床诊断为糖尿病视网膜病变（DR）患者的血样，采用rSSO HLA流式磁珠分型方法进行HLA—A、B和DRB1基因定型．统计DR患者HLA—A、B和DRB1三个基因座的基因频率；并引用以往本实验室调查的汉族健康对照人群的HLA基因频率数据，采用Woolf法计算相对危险度值。结果48例DR患者中。HLA—A、B基因频率的分布与正常对照组无显著差异．而DR患者HLA-Ⅱ类DRB1基因．DRB1＊01基因频率显著高于正常对照组．而DRBI＊12基因频率显著低于正常对照人群，计算RR值分别为5．32和0．34。结论DR患者HLA—A、B基因频率分布与正常对照人群无显著差异，但HLA—DRB1基因与DR具有相关性。
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| 关 键 词： | 糖尿病视网膜病变 候选基因 人类白细胞抗原 危险系数 |
A study on the correlation of diabetic retinopathy with HLA-A, B and DRB1 alleles |
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| YANG Baocheng,WANG Daming,GAO Suqing,et al..A study on the correlation of diabetic retinopathy with HLA-A, B and DRB1 alleles[J].Jiangxi Journal of Medical Laboratory Sciences,2008(3):242-244. |
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| Authors: | YANG Baocheng WANG Daming GAO Suqing |
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| Affiliation: | YANG Baocheng,WANG Daming,GAO Suqing,et al. Shenzhen Blood Center,Shenzhen 518035,China |
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| Abstract: | Objective To study the correlation of diabetic retinopathy (DR) with HLA-A, B and DRB1 alleles. Methods A total of 48 peripheral blood samples from patients with diabetic retinopathy were collected in this study, the genomic DNA for each sample was genotyped at HLA-A, B and DRB1 loci by luminex flow array assay. The gene frequencies of the DR group were compared with our previously-reported HLA gene frequencies data obtained from healthy individuals, the relative risk (RR) value was calculated according to ... |
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| Keywords: | Diabetic retinopathy Candidate gene Human leukocyte antigen Relative risk |
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