| 经由三氟甲基自由基的三氟甲基化反应研究进展 |
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| 引用本文： | 王兮,张艳,王剑波.经由三氟甲基自由基的三氟甲基化反应研究进展[J].中国科学:化学,2012(10):1417-1427. |
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| 作者姓名： | 王兮 张艳 王剑波 |
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| 作者单位： | 生物有机与分子工程教育部重点实验室；北京分子科学国家实验室；北京大学化学与分子工程学院,北京100871 |
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| 基金项目： | 致谢感谢国家重点基础研究计划（973计划,2012CB821600）和国家自然科学基金（21072009,20902005,20832002）的支持;感谢课题组成员肖卿、莫凡洋、邱螟、杨扬、冯嘉杰、张松南、许言、叶宇轩给予的热心帮助、建设性意见和学术讨论. |
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| 摘 要： | 含有三氟甲基的有机分子在功能材料、农业化学品、制药等领域具有广泛应用，发展三氟甲基化的新方法是有机化学中的热点．通过产生三氟甲基自由基形成碳碳键是三氟甲基化的重要策略．本文依据三氟甲基自由基产生的不同方式，分3部分介绍三氟甲基自由基经由的碳碳键形成反应．
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| 关 键 词： | 三氟甲基 自由基 碳碳键形成 有机合成 |
Trifluoromethylation recations through trifluoromethyl radical |
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| WANG Xi,ZHANG Yan,WANG JianBo.Trifluoromethylation recations through trifluoromethyl radical[J].Scientia Sinica Chimica,2012(10):1417-1427. |
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| Authors: | WANG Xi ZHANG Yan WANG JianBo |
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| Affiliation: | ＊ Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education; Beijing National Laboratory for Molecular Sciences (BNLMS); College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China |
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| Abstract: | Organic molecules that contain trifluoromethyl group have found wide applications in diverse areas such as functional materials, agrochemicals, pharmaceuticals and so on. Consequently, the development of novel methods of trifluoromethylation has become a hot topic in recent years. In this context, carbon-carbon bond formation through trifluoromethyl radical is an important strategy. In this review, the recent development of carbon-carbon bond formation through trifluoromethyl radical has been discussed according to the different approach toward trifluoromethyl radicals. |
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| Keywords: | trifluoromethyl radicals carbon-carbon bond formation organic synthesis |
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