降尿酸肽对高尿酸血症的作用及研究进展

降尿酸肽是食物蛋白经酶解得到的具有降尿酸作用的肽类化合物.高尿酸血症会引发痛风、心血管疾病、肾病和糖尿病等一系列代谢综合征,严重威胁人类健康.而临床上,许多降尿酸药物具有毒副作用,因此,开发安全有效的降尿酸肽具有实际应用意义.本文从高尿酸血症的发病机理、常用的建模方法、降尿酸肽与黄嘌呤氧化酶结合的构效关系及其体内活性评...

Recent Progress in Research on Hyperuricemia and Uric Acid-Lowering Peptides

The enzymatic hydrolysis of food proteins can produce uric acid-lowering peptides.Hyperuricemia can cause a series of metabolic syndromes such as gout,cardiovascular disease,kidney disease and diabetes,seriously threatening human health.Numerous uric acid-lowering drugs have toxic and side effects clinically.Therefore,it is of practical significance to develop more safe and effective uric acid-lowering peptides.This article summarizes the pathogenesis of hyperuricemia,the methods commonly used to establish animal models of hyperuricemia,the structure-activity relationship between uric acid-lowering peptides and xanthine oxidase,and the current status of research on the in vivo activity of uric acid-lowering peptides.Finally,we conclude with an outlook on future research directions.This article aims to provide theoretical support for the development and research of uric acid-lowering peptides.