| 肿瘤乏氧和乏氧分子影像进展 |
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| 引用本文： | 程竞仪[综述],;耿道颖,;章英剑[审校]. 肿瘤乏氧和乏氧分子影像进展[J]. 上海医学影像, 2014, 0(3): 172-177 |
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| 作者姓名： | 程竞仪[综述], 耿道颖, 章英剑[审校] |
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| 作者单位： | [1]上海市质子重离子医院核医学科,上海201321; [2]复旦大学附属肿瘤医院核医学科,复旦大学上海医学院肿瘤学系,上海200032; [3]复旦大学附属华山医院放射科,上海200040 |
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| 基金项目： | 国家自然科学基金资助项目（No：81301246） |
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| 摘 要： | 乏氧是肿瘤对放化疗抵抗的主要因素之一。PET乏氧显像发展至今有近10年的历史，尽管不断有新的正电子乏氧显像剂问世，但18F-MISO仍是临床前和临床经验累积最多的显像剂。该文综述了18F-MISO在临床前及临床研究的进展，着重于肿瘤的异质性对乏氧阈值判断的影响，并与血氧水平依赖（BOLD）MRI比较。
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| 关 键 词： | PET/CT 乏氧 18F-MISO 血氧水平依赖MRI |
Tumor hypoxia and molecular imaging |
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| Affiliation: | CHENG Jing-yi, GENG Dao-ying, ZHANG Ying-jian (1.Department of Nuclear Medicine, Shanghai Proton and Heavy Ion Center, Shanghai 201321, China; 2.Department of Nuclear Medicine, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China,＂ 3.Department of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China) |
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| Abstract: | Tumor hypoxia has been a therapeutic concern since it can reduce the effectiveness of radiotherapy and chemotherapy. Although other newer hypoxia agents have shown clinical potential, 18F-MISO still is a most completed study both in preclinical and clinical practices. We reviewed the application of 18F-MISO, especially the threshold of positive hypoxia which would be impacted by tumor heterogeneity, and compared it with blood oxygenation level dependent （BOLD） MRI. |
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| Keywords: | PET/CT Hypoxia 18F-MISO Blood oxygenation level-dependent MP.I |
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