不同血糖水平孕妇糖脂代谢变化特征研究

目的：探讨不同血糖水平孕妇血糖血脂的变化特征。方法：选取在本院进行产检的孕妇152例，依据有无糖尿病分成正常妊娠组（82例）和妊娠糖尿病（GDM）组（70例），另设同期在本院体检未怀孕健康妇女77例为对照组，分别检测总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）水平。结果：妊娠组TC、TG和LDL—C浓度均高于对照组，HDL-C浓度低于对照组，差异有统计学意义（P〈0．05）；妊娠组中GDM组TC、TG和LDL—C浓度高于正常妊娠组，而HDL—C浓度要低于正常妊娠组，差异具有统计学意义（P〈0．05）；GDM患者经治疗后血糖水平明显低于治疗前，血脂除HDL—C高于治疗前，其他如TG、TC和LDL—C均低于治疗前，差异均具有统计学意义（P〈0．05）。结论：妊娠妇女的血脂水平比未孕妇女高，GDM患者血脂水平高于同期正常妊娠妇女，GDM是以高血糖为特征，同时伴有高血脂和脂代谢紊乱，GDM经治疗后血糖浓度得到明显控制，血脂紊乱得到有效纠正。

Characteristics of glucolipid metabolism of different blood glucose levels in pregnant women

Objective： To investigate the changes of blood glucose and blood lipid in pregnant women with different blood glucose levels. Methods： A total of 152 pregnant women visited our hospital for production inspection between October 2011 to August 2013 were selected. According to the presence or absence of diabetes they were divided into normal pregnancy group （82 cases） and gestational diabetes mellitus （GDM） group （70 eases）. Besides, 77 healthy non-pregnant women were also enrolled. Total the cholesterol （TC）, triglyceride （TG）, low density lipoprotein cholesterol （LDL-C） and high density lipo- protein cholesterol （HDL-C） levels were detected and compared. Result- Pregnancy group showed significant higher TC, TG and LDL-C concentrations than those in the control group, but the concentration of HDL-C was lower than the control group, there was statistically significant difference （P〈0.05） ; TC, TG and LDL-C concentrations of GDM group were higher than that in healthy pregnancy group, but the concentration of HDL-C is lower than that of normal pregnancy group （P〉0.05） ; After treatment blood glucose level of GDM group was significantly lower than that before treatment （P〈0.05）, except HDL- C, TG, TC and LDL-C were all lower than that before treatment （P〉0.05）. Conclusion. Blood lipid lev- els in pregnant women were higher than that in non-pregnant women, blood lipid levels in patients with GDM is higher than that of hormal pregnant women, GDM is characterized by hyperglycemia, accompa- nied by high cholesterol and lipid metabolism, blood glucose control in patients with GDM is significant af- ter the treatment, dyslipidemia has been rectified effectively.