高胆固醇血症红细胞形态扫描电镜观察

 目的 探讨高胆固醇血症红细胞形态变化及发病机制.方法 以扫描电镜观察20例高胆固醇血症(>6 mmol/L)临床亚健康人血红细胞形态.结果 所选20例高胆固醇血症(>6 mmol/L)临床亚健康人血红细胞均有不同程度形态变异.结论 高胆固醇血症红细胞不仅存在膜组分的变化,同时膜蛋白和膜骨架受损及膜内外环境的劣化可能是导致其形态变异、功能受限的原因所在.

Configuration of red cells in subjects with hypercholesterolemia on scanning electron microscopy

Objective To study the heteromorphosis and pathogenesis of erythrocytes in hypercholesterolemia. Methods Configuration of erythrocytes in twenty sub - health subjects with hypercholestemlemia（ 〉 6 mmol/L） was observed by SEM. Results In all the subjects erythrocytes had morphologic change to varying extent. Conclusions In hypemholesterolemia, not only the membranous constitution of trythrocytes changed but also membrane protein and erythrocyte membrane skeleton were damaged, and the extramembranous or intramembranous milieu deteriorated; these are causes of the heteromorphosis and the hypofunction of the erythrocytes in hypercholesterolemia.