Pain in women with knee and/or hip osteoarthritis is related to systemic inflammation and to adipose tissue dysfunction: Cross-sectional results of the KHOALA cohort |
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| Affiliation: | 1. Hôpitaux de Paris (AP-HP), Rheumatology department, Saint-Antoine Hospital, DMU 3iD, 184 rue du Faubourg Saint-Antoine, Paris 75012, France;2. Sorbonne Université, 15-21 Rue de l''École de Médecine, Paris 75006, France;3. Inserm UMRS_938, CRSA, 19 Rue de Chaligny, Paris 75012, France;4. Inserm CIC 1433 CHRU de Nancy, Université de Lorraine, Hôpitaux de Brabois, Allée du Morvan, Vandoeuvre-lès-Nancy 54500, France;5. Université de Lorraine, EA 4360, APEMAC, 9 avenue de la Forêt de Haye, BP20199, Vandoeuvre-lès-Nancy 54505, France;6. Université de Caen Normandie, UMR-S 1075, 2 rue des Rochambelles, Caen cedex 5 14032, France;7. Rheumatology department, CHU de Caen, Avenue de la Côte de Nacre, Caen 14000, France;8. AP-HP, Hôpital Tenon, Service de Biochimie et Hormonologie, UF Bio-marqueurs inflammatoires et métaboliques, 1 rue de la Chine, Paris 75020, France;9. AP-HP, Hôpitaux Universitaires Henri Mondor, Département de Biochimie-Pharmacologie-Biologie Moléculaire-Génétique Médicale, 51 Avenue du Maréchal de Lattre de Tassigny, Créteil 94010, France;10. Rheumatology department, DMU locomotion, Lariboisière Hospital, AP-HP, 2 rue Ambroise Paré, Paris 75010, France;11. Inserm U1132, Paris University, 2 rue Mabroise Paré, Paris 75010, France;12. AP-HP, Hôpitaux Universitaires Henri Mondor, Rheumatology department, Paris 12 University UPEC, 51 Avenue du Maréchal de Lattre de Tassigny, Créteil 94010, France;1. Division of Rheumatology, Harbor-UCLA Medical Center and Lundquist Institute for Biomedical Innovation, 1124 West Carson Street, Building E4-R17, Torrance, CA 90502, USA;2. Division of Cardiology, Harbor-UCLA Medical Center and Lundquist Institute for Biomedical Innovation, Torrance, CA, USA;1. Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San Raffaele, via Olgettina 60, 20132, Milan, Italy;2. Vita-Salute San Raffaele University, via Olgettina 60, 20132, Milan, Italy;1. Hospital for Special Surgery, Department of Medicine, Division of Rheumatology, 535 East 70th Street, New York, NY 10021, United States;2. Weill Cornell Medicine, Department of Healthcare Policy and Research, 402 East 67th Street, New York, NY 10065, United States;3. Weill Cornell Medicine, Department of Medicine, Division of General Internal Medicine, 420 East 70th Street, 3rd Floor, New York, NY 10065, United States;4. Weill Cornell Medicine, Department of Medicine, Division of Cardiology, 520 East 70th Street, New York, NY 10021, United States;1. Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Marmara University, Istanbul, Turkey;2. Cerrahpasa Medical School, Department of Pediatrics, Division of Pediatric Rheumatology, Istanbul University-Cerrahpasa, Istanbul, Turkey;1. Division of General Internal Medicine and Primary Care, Brigham and Women''s Hospital, Boston, MA, United States;2. Harvard Medical School, Boston, MA, United States;3. Rheumatology Unit, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA, United States;4. Clinical Epidemiology Program, Mongan Institute, Massachusetts General Hospital, Boston, MA, United States;1. Department of Rheumatology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel;2. Center for Prognostic Studies in the Rheumatic Diseases, Krembil Research Institute, University Health Network, Toronto, ON Canada;3. Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON Canada;4. Department of Medicine, University of Toronto, Toronto, ON Canada;5. Institute of Medical Science, University of Toronto, Toronto, ON Canada;6. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON Canada |
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| Abstract: | BackgroundConsidering the role of metabolic diseases in osteoarthritis (OA), we investigated whether biomarkers of adipose tissue dysfunction could be associated with OA-related pain.DesignWe cross-sectionally analyzed patients with knee and/or hip OA at inclusion in the KHOALA cohort. We used visual analogic scale (VAS) for pain, the Western Ontario and McMaster Universities Arthritis Index (WOMAC) and Osteoarthritis Knee and Hip Quality of Life (OAKHQOL) pain subscores. At inclusion, we measured ultra-sensitive CRP (usCRP), leptin and adiponectin for calculation of leptin:adiponectin ratio (LAR), a marker of adipose tissue dysfunction associated with central adiposity, high-molecular-weight adiponectin, visfatin and apolipoproteins. Univariate and multivariable analyses using stepwise linear regression models were performed to search for correlation between pain assessments and these biomarkers, with systematic adjustment on age.ResultsIn 596 women with hip and/or knee OA, multivariable analyses indicated that higher pain intensity was associated with higher LAR (VAS pain: β=0.49; p = 0.0001, OAKHQOL pain: β=-0.46; p = 0.0002, WOMAC pain: β=0.30; p = 0.001) in the whole group as well as in hip or knee OA patients considered separately. Pain intensity correlated also with usCRP level (VAS pain: β= 0.27; p = 0.02, OAKHQOL pain: β =-0.30; p = 0.01) and Kellgren-Lawrence score. In 267 men, no correlation between biomarkers and pain was found.ConclusionSerum LAR and usCRP level are associated with pain level, independently of radiographic structural severity in women with hip and/or knee OA, emphasizing the role of adipose tissue dysfunction and of meta-inflammation in pain experience in the female population. |
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