CYPlA1、GSTMl基因多态性及环境因素与新疆哈萨克族食管癌家族聚集性的相关性研究

目的探讨CYPlAl、GSTMI基因多态性及环境因素与新疆哈萨克族食管癌家族聚集性发生的关系。方法通过检测86例新疆哈萨克族食管癌家族及82例对照家族外周血CYPlAl、GSTMl基因的多态性，并通过对环境危险因素进行现场问卷调查，探讨CYPlAl、GSTMI基因和环境因素在新疆哈萨克族食管癌家族聚集性中所起的作用。结果在新疆哈萨克族食管癌家族与对照家族之间cⅥ，1A1MspI、GSTMl不同基因型的分布频率差异均有统计学意义（P〈0．05），MspI突变型和GSTMl缺失型之间交互作用显著增加食管癌家族集聚性，OR值为3．193（95％CI：1．645—3．376），Logistic多因素分析显示新疆哈萨克族食管癌家族聚集性的发生与饮水情况、摄人较多新鲜蔬菜水果、CYPlAl基因MspI多态性等3个因素具有相关性，其中摄入较多新鲜蔬菜水果（OR=0。278，95％CI：0．137—0．551）是新疆哈萨克族食管癌家族聚集性的保护因素，饮用河水（OR=3．468，95％CI：1．562—6．551）、CYPlAI基因Mspl多态性的突变表型（OR=2．732，95％CI：1．741—3．886）是新疆哈萨克族食管癌家族聚集性的危险因素。结论CYPlAl、GSTMl基因多态性在新疆哈萨克族食管癌家族聚集性中起了一定的作用，饮用河水、CYPlAl基因Mspl突变表型是新疆哈萨克族食管癌家族聚集性的危险因素，可能与这些家族成员食管癌高发有关。

Study of the correlation about CYP1A1 gene, GSTM1 gene polymorphism and environmental factors with the family aggregation of xinjiang kazakh esophageal carcinoma

Objective To investigate relationship between the gene polymorphism of CYP1A1 ,GSTMI, environmental factors and the family aggregation of XinJiang Kazakh es@ageal carcinoma. Methods To explore the roles of CYPI A1, GSTM1 genes and environmental factors that played in the family aggregation of XinJiang Kazakh esophageal carcinoma, we tested ＇above such gene polymorphisms in the peripheral blood of 86 cases of XinJiang Kazakh esophageal carcinoma family and 82 cases of control family, and did the on - site survey about the environmental risk factors. Results There were statistic differences between XinJiang Kazakh esophageal car- cinoma family and control family in the distribution frequency of gene types of CYP1AI MspI, GSTM1 （P = O. 002, P = 0.001 ）. Combined effects of the CYP1AI MspI mutision genotype and GSTMI null genotype indicated a notable interaction on the increased family aggregation of XinJiang Kazakh esophageal carcinoma,with an OR of 3. 571 （95% CI = 1. 738 - 3. 346）. Multiple logistic regression showed that water type, intaking of fresh vegeta- bles, fruits, and CYP1 A1 MspI mutision genotype are correlated with the family aggregation of XinJiang Kazakh e- sophageal carcinoma（ P = 0.005,P = 0.013, P = 0.001 ）. The intaking of fresh vegetables and fruits was protec- tive factor（ OR = 0. 278,95% CI = 0. 137 - O. 551 ）, and the water type（ OR = 3. 468,95% CI = 1. 562 - 6. 551 ）, and CYPI AI MspI mutision genotype（ OR = 2. 732,95% CI = 1. 741 - 3. 886） were the risk factors for the familyaggregation of XinJiang Kazakh esophageal carcinoma. Conclusion The polymorphism of CYPIAI ,GSTM! genes plays a role in the family aggregation of XinJiang Kazakh esophageal carcinoma. Drinking tile river water and CYP1AI MspI mutision genotype are risk factors for the family aggregation of XiltJiang Kazakh esophageal carcino- ma,which maybe correlate with the high esophageal carcinoma incidence rate in the member of XinJiang Kazakh e- sophageal carcinoma family.