| 降钙素基因相关肽能神经纤维在蛛网膜下腔出血大鼠脑底动脉的分布 |
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| 引用本文： | 祝高春,李桂林,薛国勇,林雪群.降钙素基因相关肽能神经纤维在蛛网膜下腔出血大鼠脑底动脉的分布[J].江西医学院学报,2008,48(5):5-7. |
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| 作者姓名： | 祝高春 李桂林 薛国勇 林雪群 |
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| 作者单位： | [1]南昌大学医学院脑血管研究所,南昌330006 [2]南昌大学医学院生理教研室,南昌330006 |
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| 摘 要： | 目的探讨大鼠脑底动脉降钙素基因相关肽（CGRP）能神经纤维在蛛网膜下腔出血（SAH）诱发脑血管痉挛中的分布及其作用。方法Wistar大鼠随机分为正常组、SAH组（5 d,14 d）。SAH组大鼠取股动脉自体血注入蛛网膜下腔,应用免疫组织化学ABC法,对正常组、SAH组大鼠脑底动脉CGRP能神经纤维变化进行观察。结果正常组大鼠脑底动脉可见棕褐色、细线状CGRP能免疫反应阳性纤维;SAH 5 d组大鼠脑底动脉与正常组比较CGRP能神经纤维密度明显减少（P〈0.05）;SAH 14 d组大鼠脑底动脉与正常组比较CGRP能神经纤维密度无明显变化。结论脑底动脉CGRP能神经纤维在蛛网膜下腔出血诱发脑血管痉挛的病理生理过程中可能发挥重要的作用。
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| 关 键 词： | 蛛网膜下腔出血 脑血管痉挛 降钙素基因相关肽 神经纤维 动物 实验 大鼠 |
The Innervation of Calcitonin Gene-related Peptide Innervation on Cerebral Atery in the Rat after Subarachnoid Hemorrhage |
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| ZHU Gao-chuna,LI Gui-linb,XUE Guo-yonga,LIN Xue-quna.The Innervation of Calcitonin Gene-related Peptide Innervation on Cerebral Atery in the Rat after Subarachnoid Hemorrhage[J].Acta Academiae Medicinae Jiangxi,2008,48(5):5-7. |
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| Authors: | ZHU Gao-chuna LI Gui-linb XUE Guo-yonga LIN Xue-quna |
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| Affiliation: | a.Institute of Cerebral Vessels Research;b.Department ofPhysiology;Nanchang University Medical College;Nanchang 330006;China |
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| Abstract: | Objective To explore the innervation of calcitonin gene-lated peptide(CGRP) nerve fiberss and its effect in rats during cerebral vasospasm induced by subarachnoid hemorrahage(SAH).Methods 42 Wistar rats were randomly divided into three groups:normal(negative control),5d SAH,and 14d SAH group.For SAH groups,SAH was induced by immediate injection into the subarachoid of autologous arterial blood,which was freshly gotten from femoral artery.SAH let last 5 days for 5d group,while 14days for 14d group.The densit... |
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| Keywords: | subarachnoid hemorrhage cerebral vasospasm calcitonin gene-related peptide nerve fiber animal experiment rats |
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