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Combination effect of phospholipids and n-3 polyunsaturated fatty acids on rat cholesterol metabolism |
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| Authors: | Ryota Hosomi Kenji Fukunaga Midori Fukao Munehiro Yoshida Hirofumi Arai Seiji Kanda Toshimasa Nishiyama Teruyuki Kanada |
| Affiliation: | 1. Department of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Suita, Osaka, 564-8680, Japan 2. Division of Human Living Sciences, Tottori College, Kurayoshi, Tottori, 682-8555, Japan 3. Department of Biotechnology and Environmental Chemistry, Kitami Institute of Technology, Kitami, Hokkaido, 090-8507, Japan 4. Department of Public Health, Kansai Medical University, Moriguchi, Osaka, 570-8506, Japan 5. Department of Research & Development, Bizen Chemical, Okayama, 709-0716, Japan |
| Abstract: | This study evaluated phospholipids (PLs) containing n-3 polyunsaturated fatty acids (n-3 PUFAs) for their specific inherent effects and effects due to a combination of the presence of glycerophosphate structure and n-3 PUFAs on cholesterol metabolism in rats. Rats were fed a diet of AIN-93G containing soybean oil (SO, 7%), SO (5.8%)+fish oil (1.2%), SO (5.2%)+soybean PLs (1.8%), SO (5.2%)+PLs containing n-3 PUFAs (1.8%), and SO (4.0%)+fish oil (1.2%)+soybean PLs (1.8%). Diets with PLs containing n-3 PUFAs, and soybean PLs in combination with fish oil, resulted in decreased serum and liver cholesterol levels through enhancement of fecal cholesterol excretion and suppression of liver sterol regulatory element binding protein-2 mRNA expression compared with the diet containing soybean oil alone. This study shows that soybean PLs with added triacylglycerol that included n-3 PUFAs have the same effects on cholesterol metabolism as PLs containing n-3 PUFAs, and that these could be of benefit to people. |
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