超声引导下关节腔内注射高渗葡萄糖溶液治疗高原地区膝关节骨性关节炎

目的 观察以超声引导下关节腔内注射高渗葡萄糖(HG)治疗高原地区膝关节骨性关节炎的价值。方法 纳入91例高原地区膝关节骨性关节炎患者共124个病变膝关节,根据治疗药物将膝关节分为20%HG组(n=67)、25%HG组(n=42)及玻璃酸钠组(n=15);比较治疗前、后临床及超声评分,评估疗效。结果 治疗后第12、48周,3组视觉模拟评分法(VAS)评分均较治疗前降低(P均<0.05),20%HG组和25%HG组Lysholm评分均较治疗前升高(P均<0.05)。25%HG组治疗前与治疗后第12周Lysholm评分差值、治疗前与治疗后第48周VAS评分差值均高于20%HG组(P均<0.05)。20%HG组治疗后第48周关节渗出评分较治疗前降低(P<0.05),治疗后第12及48周滑膜血流评分较治疗前降低(P均<0.05);25%HG组治疗后第48周关节渗出评分较治疗前降低(P<0.05),治疗后第12及48周滑膜增生和滑膜血流评分均较治疗前降低(P均<0.05);玻璃酸钠组治疗后第48周关节渗出评分较治疗前降低(P<0.05),治疗后第12...

Ultrasound-guided intra-articular injection of hypertonic glucose for treating knee osteoarthritis in plateau area

Objective To observe the value of ultrasound-guided intra-articular injection of hypertonic glucose (HG) for treating knee osteoarthritis in plateau area. Methods Ninety-one patients with knee osteoarthritis in plateau area (124 affected knee joints) were enrolled. The knee joints were divided into 20%HG group (n=67), 25%HG group (n=42) or sodium hyaluronate group (n=15) based on the medication. Clinical and ultrasound scores were compared before and after treatment, and the efficacy of injection of HG was evaluated. Results At the 12th and 48th weeks after treatment, visual analog scale (VAS) scores decreased in all 3 groups (all P<0.05), and Lysholm scores of 20%HG group and 25%HG group increased compared to those before treatment (all P<0.05). The difference of Lysholm score before and in the 12th week after treatment, and of VAS score before and in the 48th week after treatment of 25%HG group were higher than those of 20%HG group (both P<0.05). The joint exudation score of 20%HG group decreased in the 48th week after treatment compared to that before treatment (P<0.05), and the synovial blood flow score decreased in the 12th and 48th weeks after treatment compared to those before treatment (both P<0.05). The joint exudation score of 25%HG group decreased in the 48th week after treatment compared to that before treatment (P<0.05), and the synovial hyperplasia and synovial blood flow score decreased in the 12th and 48th weeks after treatment compared to before treatment (all P<0.05). The joint exudation score of sodium hyaluronate group decreased in the 48th week after treatment compared to that before treatment (P<0.05), and the synovial hyperplasia score decreased in the 12th and 48th weeks after treatment compared to that before treatment (both P<0.05). Conclusion Ultrasound-guided intra-articular injection of HG, esp. 25%HG, had certain value for treating knee osteoarthritis in plateau area.