藏、汉族健康人对安替比林及醋氨酚代谢的种族差异

用随机交叉设计,研究了藏、汉族健康人安替比林和醋氨酚的代谢差异。16例汉族人安替比林T_1/2为18.8±4.89h,17例藏族人为15.0±3.02h(P<0.05),汉族人安替比林清除率是1.35±0.37L·h^-1,藏族人是1.71±0.44Lt·h^-1(P<0.05)。汉族人醋氨酚T_1/2是3.1±0.86h,藏族人是3.2±1.12h(P>0.05)。实验结果表明,藏、汉族健康人安替比林的代谢有显著差异,藏族人安替比林清除率比汉族人增加了20%。藏、汉族醋氨酚的代谢无明显差异。

ETHNIC DIFFERENCES IN DISPOSITION OF ANTIPYRINE AND ACETAMINOPHEN BETWEEN TIBETAN AND HAN HEALTHY VOLUNTEERS

The differences in disposition of antipyrine and acetaminophen between Tibetan and Han healthy volunteers were studied in a randomized crossover design. The half-life of antipyrine was found to be 18.8±4.89 h in 16 Han and 15.0±3.02 h in 17 Tibetan(P<0.05) and the clearance was 1.35±0.37 L·h^-1 in Han and 1.71±0.44 L·h^-1 in Tibetan(P<0.05). The half-life of acetaminophen was 3.1±0.86 h in Han and 3.2±1.12 h in Tibetan(P>0.05).The experimental results indicate that the disposition of antipyrine between Tibetan and Han healthy volunteers significantly differed,the clearance of antipyrine in Tibetan increased by 20%,but the disposition of acetaminophen between the two ethnic groups showed no difference.