Macromolecules inhibit calcium oxalate crystal growth and aggregation in whole human urine |
| |
| Authors: | K A Edyvane C M Hibberd R M Harnett V R Marshall R L Ryall |
| |
| Affiliation: | 1. ISEL — Instituto Superior de Engenharia de Lisboa, Instituto Politécnico de Lisboa, Rua Conselheiro Emídio Navarro 1, 1959-007 Lisbon, Portugal;2. Centro de Física Teórica e Computacional, Faculdade de Ciências da Universidade de Lisboa Campo Grande, Edifício C8, 1749-016 Lisbon, Portugal |
| |
| Abstract: | Removal of macromolecules with Mr greater than 10,000 had no discernible effect on the detectable nucleation of calcium oxalate crystals from undiluted human urine, but promoted the deposition of crystalline material and markedly increased the degree of aggregation of the precipitated crystals. Calcium oxalate crystals and crystal aggregates precipitated from ultrafiltered urine were, on average, 68% larger than those deposited from whole urine. These findings suggest that urinary macromolecules play a key role in preventing calcium oxalate kidney stone disease by inhibiting the formation of large crystal aggregates and thereby reducing the probability of particle retention in the kidney tubules. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
