| 液相色谱-质谱联用法检测非法制剂中的醋酸泼尼松 |
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| 引用本文： | 姜建国,张西如. 液相色谱-质谱联用法检测非法制剂中的醋酸泼尼松[J]. 中国药业, 2008, 17(21): 28-29 |
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| 作者姓名： | 姜建国 张西如 |
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| 作者单位： | 河北省药品检验所,河北,石家庄,050011 |
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| 摘 要： | 目的建立检测非法制剂中醋酸泼尼松的专属性方法。方法采用液相色谱-质谱联用法，选用Venusil MP C18柱（150mm×4．6mm，5μm），以0．01mol／L醋酸铵-乙腈（45：55）为流动相，对非法制剂的提取液进行液相色谱-质谱联用分析。通过与对照品的色谱、紫外及质谱行为比较，对此类非法制剂进行定量测定和定性鉴别。结果在非法制剂中均检出醋酸泼尼松，且回收率为98．77％（n=6）。结论该方法选择性强，灵敏度高，可分析检测非法制剂中的醋酸泼尼松。
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| 关 键 词： | 醋酸泼尼松 液相色谱-质谱联用法 风湿筋骨康胶囊 |
Detection of Prednisone Acetate Illegally Added in Fengshi Jingukang Capsules by LC- MS |
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| Jiang Jianguo,Zhang Xiru. Detection of Prednisone Acetate Illegally Added in Fengshi Jingukang Capsules by LC- MS[J]. China Pharmaceuticals, 2008, 17(21): 28-29 |
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| Authors: | Jiang Jianguo Zhang Xiru |
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| Affiliation: | ( Hebei Provincial Institute for Drug Control, Shijiazhuang, Hebei, China 050011) |
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| Abstract: | Objective To develop a specific method for prednisone acetate illegally added in preparations. Methods The LC-MS method was used. The Venusil MP C18 column was used with the mobile phase of 0. 01 mol/L ammonium acetate solution acetonitrile （45：55）. Prednisone acetate illegally added was quantitatively determined and qualitatively identified according to the chromatographic behavior and mass spectral data by comparison with reference substances. Results Prednisone acetate was found in the illegal preparations. The average recovery rate was 98. 77% （n =6）. Conclusion The method is selective and sensitive. It can be used to detect prednisone acetate in the illegal preparations. |
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| Keywords: | prednisone acetate LC-MS method Fengshi Jingukang Capsules |
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