长期食入抗坏血酸对国产防锈水诱发威斯塔大鼠致癌作用的影响

经40头雄威司塔大鼠长期饮用国产防锈水(含亚硝酸钠、三乙醇胺和聚乙二醇)实验表明,实验动物每天口服约75mg亚硝酸钠,两年后发生以胰腺泡型腺癌(22.5%)为主的恶性肿瘤(32.5%),并有30%的胰腺泡增生及不典型增生。另40头同规格大鼠在上述处理同时每天还经饮用水口服150mg抗坏血酸,两年后胰腺腺泡增生和胰腺癌发生率均有极显著减少,仅占2.5%,实验提示防锈水诱发胰腺癌是由于在体内合成某种亲胰腺腺泡的未知亚硝基化合物,而口服抗坏血酸对接触“防锈水”的金属切削工人可能有良好的防癌作用。

EFFECT OF LONG-TERM ASCORBIC ACID INGESTION ON THE CARCINOGENICITY OF "RUSTPROOF" FLUID IN WISTAR RATS

Ingestion of rustproof fluid comprised of sodium nitrite, triethanola-mine and polyethylene glycol (corresponding to daily intake of 75mg of sodium nitrite) for 2 years by 40 male Wistar rats induced 32.5% malignant tumors with 22.5% acinar adenocarcinoma of the pancreas and 30% hyperplasia and atypical hyperplasia of pancreatic acini. The control group receiving the same treatment together with daily intake of 150mg of accorbic acid through drinking water for 2 years had much less pancreatic hyperplasia and carcinoma (both 2.5% only). The experimental results strongly suggested that the agent causing pancreatic lesions in rats might be a new nitrosamine formed in vivo by ingredients of the ingested fluid and oral ascorbic acid ingestion could be a means of protecting the workers exposed to the fluid.