| 氯胺酮对大鼠大脑皮质、脑干、纹状体和海马Na~＋，K~＋－ATP酶活性的影响 |
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| 引用本文： | 黄卉芳,段世明,郭忠民,戴体俊.氯胺酮对大鼠大脑皮质、脑干、纹状体和海马Na~＋，K~＋－ATP酶活性的影响[J].中国药理学通报,1996(3). |
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| 作者姓名： | 黄卉芳 段世明 郭忠民 戴体俊 |
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| 作者单位： | 徐州医学院麻醉药理学教研室 |
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| 摘 要： | 大鼠ｉｐ不同剂量的氯胺酮（５０，１００，２００ｍｇ·ｋｇ－１），除小剂量（５０ｍｇ·ｋｇ－１）兴奋大脑皮质Ｎａ＋．Ｋ＋－ＡＴＰ酶活性外，其余剂量对鼠脑４个分区的酶活性均有抑制作用．５０ｍｇ·ｋｇ－１氯胺酮显著抑制海马Ｎａ＋，Ｋ＋－ＡＴＰ酶，１００ｍｇ·ｋｇ－１显著抑制大脑皮质、纹状体和海马Ｎａ＋，Ｋ＋－ＡＴＰ酶；２００ｍｇ·ｋｇ－１显著抑制脑干和海马Ｎａ＋，Ｋ＋－ＡＴＰ酶。结果提示．氯胺酮对中枢神经系统的抑制作用可能与其抑制脑组织中Ｎａ＋，Ｋ＋－ＡＴＰ酶活性有关。
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| 关 键 词： | 氯胺酮 Na～＋，K～＋－ATP酶 大脑皮质 脑干 纹状体 海马 |
Effects of ketamine on activity of Na~ , K~ -ATPase in rat cerebral cortex, brain stem,corpus striatum and hippocampus in vivo |
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| HUANG Hut-Fang, DUAN Shi-Ming, GUO Zhong-Min, DAI Ti-Jun.Effects of ketamine on activity of Na~ , K~ -ATPase in rat cerebral cortex, brain stem,corpus striatum and hippocampus in vivo[J].Chinese Pharmacological Bulletin,1996(3). |
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| Authors: | HUANG Hut-Fang DUAN Shi-Ming GUO Zhong-Min DAI Ti-Jun |
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| Abstract: | The effects of ketamine at 50,100, 200mg·kg-1(ip)on the activity of Na+,K+-ATP ase in rat cerebral cortex, brain stem,corpus striatum and hippocampus were studied.Except that Na+, K+-ATPase in cerebral cortex was activated by ketamine at 50 mg·kg-1,all other experiment groups of ketamine inhibited Na+, K+-ATPase activity in four different areas of rat brain. Ketamine at 50 mg· kg-1 significantly inhibited Na+, K+-ATPase in hippocampus, at 100 mg·kg-1Na+,K+-ATPase in cerebral cortex and corpus striatum and at 200 mg·kg-1Na+, K+-ATPase activity in brain stem and hippocampus. The results indicated that the inhibitory effect. of ketamine on the central nervons system are associated with its inhibition on Na+, K+-ATPase activity in the brain. |
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| Keywords: | ketamine Na￣+ K￣+-ATPase cerebral cortex brain stem corpus striatum hippocampus |
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