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| 静脉注射四氧嘧啶制备妊娠糖尿病大鼠动物模型 | |
| 引用本文： | 杨尚武,文梦灵,梁建华,苏薇. 静脉注射四氧嘧啶制备妊娠糖尿病大鼠动物模型[J]. 海南医学院学报, 2006, 12(2): 118-120 |
| 作者姓名： | 杨尚武 文梦灵 梁建华 苏薇 |
| 作者单位： | 1. 广东省深圳市妇幼保健院临床部产科,广东,深圳,518028 2. 中山大学附属三院,广东,广州,510630 3. 深圳市保安区中医院,广东,深圳,518000 4. 深圳市罗湖区中医院,广东,深圳,518000 |
| 基金项目： | 广东省深圳市科技局科研项目 |
| 摘 要： | 目的:探讨四氧嘧啶制备糖尿病妊娠大鼠动物模型的理想方法.方法:通过对妊娠大鼠尾静脉注射四氧嘧啶40 mg/kg,观察成功动物模型例数、转阴例数和死亡例数.比较动物模型组与正常妊娠组之间的血糖差异.结果:动物模型组注射后成模率92.3%,转阴率8.33%,死亡率3.85%.糖尿病妊娠大鼠空腹血糖明显高于正常妊娠鼠.所有转阴鼠转阴时间出现在成模1周内.结论:尾静脉注射40 mg/kg是进行妊娠大鼠实验成模的较理想方法. |
| 关 键 词： | 糖尿病,实验性 四氧嘧啶 妊娠 大鼠 |
| 收稿时间： | 2006-03-17 |
Preparation of animal diabetes model in pregnant rats byintravenous Injection of Alloxan |
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| YANG Shang-wu, WEN Meng-ling, LIANG Jian-hua,et al.. Preparation of animal diabetes model in pregnant rats byintravenous Injection of Alloxan[J]. Journal of Hainan Medical College, 2006, 12(2): 118-120 | |
| Authors: | YANG Shang-wu WEN Meng-ling LIANG Jian-hua et al. |
| Affiliation: | Clinical Gynecology Department, Shenzhen Health Hospital for Women and Children, Guangdong Shenzhen 518028, P.R.China |
| Abstract: | Objective: To investigate the proper method for establishing reliable diabetes model in pregnant rats by injecting alloxan. Methods: The pregnant rats were injected with alloxan 40 mg/kg in caudal vein and successful preparation rate, turning negative rate and mortality were observed. The blood glucose levels were compared between normal pregnant and diabetes pregnant groups. Results: The successful rate was 92.3%, turning negative rate and mortality were 8.33% and 3.85% respectively. The blood glucose level in model group was much higher than that in the control group. All recovery of turning negative happened within one week. Conclusion: Intravenous injection with alloxan 40 mg/kg is a proper method to establish diabetes model in pregnant mice. |
| Keywords: | Diabetes experimental Alloxan Pregnancy Rat |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
