Evidence for a synergistic interaction between isoprenaline and timolol on intraocular pressure in conscious rabbits |
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Authors: | J Santafe J Segarra M Garrido V Pablo MJ Martinez de Ibarreta |
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Affiliation: | Departamento de Farmacología, Facultad de Farmacia, Universidad del Pais Vasco, Vitoria, Spain. |
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Abstract: | 1. Interaction between topical isoprenaline and timolol on intraocular pressure was studied in conscious rabbits through changes of the dose-response curves. 2. Both drugs caused a dose-dependent fall of intraocular pressure mainly by reducing the aqueous humour formation. 3. When combined, timolol increased the response to submaximal concentrations of isoprenaline as well as EC50 (from 2.06 x 10(-3) M to 3.63 x 10(-3) M) and slope (from 1.21 to 1.89), but peak response to isoprenaline remained unchanged. 4. Discordance between experimental and theoretical additive curves as well as an interaction index smaller than 1 show that the interaction between both drugs is synergistic. |
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