|
|||||
|
|
| 微波法合成2-羟乙基苯并[d]异噻唑-3(2H)-酮 | |
| 引用本文： | 游诚航,王向辉,李华燕,尹学琼,杨建新,林强. 微波法合成2-羟乙基苯并[d]异噻唑-3(2H)-酮[J]. 化学研究与应用, 2012, 24(5): 778-782 |
| 作者姓名： | 游诚航 王向辉 李华燕 尹学琼 杨建新 林强 |
| 作者单位： | 1. 昆明理工大学 环境科学与工程学院,云南昆明,650093 2. 海南省精细化工工程技术研究中心,海南大学 材料与化工学院,海南海口 570228 3. 海南师范大学 化学与化工学院,海南海口,571158 |
| 摘 要： | 以苯并异噻唑-3(2H)-酮(BIT)及氯乙醇为原料微波法合成了2-羟乙基苯并[d]异噻唑-3(2H)酮。考察了氢氧化钠量,氯乙醇用量,反应时间,反应温度对反应的影响,经正交实验设计得到了最佳反应条件,最佳反应条件下收率为83.3%。结果表明,与传统工艺相比,微波技术合成2-羟乙基苯并[d]异噻唑-3(2H)-酮的方法具有操作方便、收率高等特点,具有一定的应用价值。 |
| 关 键 词： | 2-羟乙基苯并[d]异噻唑-3(2H)酮 微波 合成 正交试验 |
Synthesis of 2-hydroethyl-benzo [d] isothiazole-3 (2H) -one under microwave irradiation |
|
| YOU Cheng-hang , WANG Xiang-hui , LI Hua-yan , YIN Xue-qiong , YANG Jian-xin , LIN Qiang. Synthesis of 2-hydroethyl-benzo [d] isothiazole-3 (2H) -one under microwave irradiation[J]. Chemical Research and Application, 2012, 24(5): 778-782 | |
| Authors: | YOU Cheng-hang WANG Xiang-hui LI Hua-yan YIN Xue-qiong YANG Jian-xin LIN Qiang |
| Affiliation: | 1.Hainan Provincial Fine Chemical Engineering Research Center,Material and Chemical Engineering College,Hainan University,Haikou 570228,China; 2.Institute of Environmental Science and Engineering,Kunming University of Science and Technology,Kunming 650093,China; 3.College of Chemistry and Chemical Engineering,Hainan Normal University,Haikou 571158,China) |
| Abstract: | Microwave irradiation was used to the synthesis of 2-hydroethyl-benzo[d]isothiazole-3(2H)-one from the starting material benzo[d]isothiazole-3(2H)-one and 2-chloroethanol.The influence of the mol ratio of sodium hydroxide and 2-chloroethanol was studied,as well as the time and the temperature of the reaction.The optimum reaction condition was determined through orthogonal experiment.Under the optinum reaction condition,the refined yield reached 83.3%.The result showed that the microwave synthesis of 2-hydroethyl-benzo[d]isothiazole-3(2H)-one was more convenient than traditional ones,with faster reaction speed and higher yield.Thus,it could be a promissing way for utilization. |
| Keywords: | 2-hydroethylbenzo[d]isothiazole-3(2H)-one microwave synthesis orthogonal experiment |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |
