Circadian feeding rhythm after hypothalamic knife-cut isolating suprachiasmatic nucleus |
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| Authors: | T Nishio S Shiosaka H Nakagawa T Sakumoto K Satoh |
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| Affiliation: | Division of Protein Metabolism, Institute for Protein Research, Osaka University 5311 Yamada-Kami, Suita City, Osaka 565, Japan;Department of Neuroanatomy, Institute of Higher Nervous Activity, Osaka University, Medical School Osaka 530, Japan |
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| Abstract: | Bilateral parasagittal knife-cut between the suprachiasmatic nucleus (SCN) and lateral hypothalamic area (LH) or coronal knife-cut between the SCN and ventromedial hypothalamic nucleus (VMH) resulted in a partial loss of the circadian feeding rhythm in rats; after either operation the rats consumed about 30% of their total daily food intake during the light period. However, after the parasagittal and coronal knife-cuts were made in combination, the circadian feeding rhythm was completely lost (50% food intake during the light period). Rats which lost the circadian feeding rhythm partially or completely showed neither obesity nor anorexia. These findings suggest that there are dual informational pathways from the SCN, possibly between the SCN and LH and between the SCN and VMH, through which circadian time signals generated in the SCN are transmitted to the LH and VMH to drive the circadian feeding rhythm. |
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| Keywords: | Circadian feeding rhythm Hypothalamic knife-cuts Suprachiasmatic nucleus |
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