| 灯盏花素抑制去甲肾上腺素-而增强高钾-锈发的细胞内钙升高 |
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| 引用本文： | 雷开键,黄燮南,吴芹,陆远富,石京山.灯盏花素抑制去甲肾上腺素-而增强高钾-锈发的细胞内钙升高[J].川北医学院学报,2004,19(4):6-7. |
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| 作者姓名： | 雷开键 黄燮南 吴芹 陆远富 石京山 |
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| 作者单位： | 遵义医学院药理学教研室,贵州,遵义,563003;遵义医学院药理学教研室,贵州,遵义,563003;遵义医学院药理学教研室,贵州,遵义,563003;遵义医学院药理学教研室,贵州,遵义,563003;遵义医学院药理学教研室,贵州,遵义,563003 |
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| 摘 要： | 目的观察灯盏花素(Breviscapine,Bre)对去甲肾上腺素(NA)、高钾所致的血管平滑肌细胞内游离钙浓度Caa+]i的影响。方法利用钙荧光指示剂Fura-2／AM负载的家兔血管平滑肌细胞,动态地观察Bre对NA及高钾所诱发Caa+]i的改变。结果Bre可抑制含Ca2+液中NA所诱发的Caa+]i的升高,但对高钾所致Caa+]i的升高却有增强作用。结论Bre可能通过抑制受体依赖性钙通道而降低Caa+]i,但却能增强电压依赖性钙通道而增高Caa+]i。
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| 关 键 词： | 灯盏花素 兔胸主动脉条 细胞内游离钙 去甲肾上腺素氯化钾 |
| 文章编号： | 1005-3697(2004)04-0006-02 |
| 修稿时间： | 2004年10月18日 |
Bre inhibited [ Caa+ ]i elevation induced by NAwhile enhanced that induced by kalium chloride |
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| LEI Kai-jian,HUANG Xie-nan,WU Qin,LU Yuan-fu,SHI Jing-shan.Bre inhibited [ Caa+ ]i elevation induced by NAwhile enhanced that induced by kalium chloride[J].Journal of North Sichuan Medical College,2004,19(4):6-7. |
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| Authors: | LEI Kai-jian HUANG Xie-nan WU Qin LU Yuan-fu SHI Jing-shan |
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| Abstract: | Objective To observe the effects of Bre on intracellular free calcium(Caa+]i) elevation of culcured smooth muscle cells induced by NA and high concentration of kalium chloride.Methods Using fluorescence indicator fura-2/AM-loaded cultured smooth muscle cells of rabbit aorta,to observe Caa+]i changes induced by NAand kalium chloride in the presence of Ca2+.Results Bre could inhibit Caa+]i elevation induced by NA while it could enhance that induced by kalium chloride.Conclusion Bre may decrease Caa+]i through receptor-dependent calcium channels,while it can increase Caa+]i through voltage-dependent calcium channels. |
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| Keywords: | Breviscapine Thoracic aorta strips of rabbit KG1 Noradrenaline Intracellular free calcium |
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