| 盐酸头孢吡肟的合成新方法 |
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| 引用本文： | 王喜军,于波. 盐酸头孢吡肟的合成新方法[J]. 黑龙江医药, 2008, 21(4) |
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| 作者姓名： | 王喜军 于波 |
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| 作者单位： | 哈药集团制药总厂,黑龙江哈尔滨,150086;哈药集团制药总厂,黑龙江哈尔滨,150086 |
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| 摘 要： | 介绍盐酸头孢吡肟的一种合成新方法.此方法以7-氨基-3[(1-甲基-1-吡咯烷基)甲基]头孢-3-烯-4羧酸盐酸盐和2-甲氧亚氨基-2-(2-氨基-4-噻唑基)-(z)-乙酸二乙基磷酰活性酯为起始原料,具有收率高,杂质低,成本低等优点,并利用核磁共振和质谱对产物进行了表征.
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| 关 键 词： | 头孢菌素 盐酸头孢吡肟 合成 |
New Synthetic Method of Cefepime Dihydrochloride |
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| Wang Xijun,et al General Pharm.Factory Harbin Pharmaceutical Group Co.,Ltd,Harbin. New Synthetic Method of Cefepime Dihydrochloride[J]. Heilongjiang Medicine, 2008, 21(4) |
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| Authors: | Wang Xijun et al General Pharm.Factory Harbin Pharmaceutical Group Co. Ltd Harbin |
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| Abstract: | One new synthetic method of cefepime dihydrochloride using 7-amino-3-[(1-methyl-1- pyrrolidino)methy]ceph-3-em-4-carboxylate hydrochloric salt and diethyl phosphoryl (Z)-2-(2-aminothiazol-4 -yl)-2-(methoxyimino) acetate as the startng materials was developed with high yield,lowi impurities,and low costetc. LC-MS and 13C-NMR were used to characterize the structure of the compound. |
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| Keywords: | cephalosporins cefepime synthesis |
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