甘精胰岛素联合阿卡波糖治疗老年2型糖尿病的临床价值

目的 探讨老年2型糖尿病患者治疗中甘精胰岛素联合阿卡波糖的临床应用价值.方法 202例老年糖尿病患者,经随机数字表法分为对照组及研究组,每组101例.对照组行单纯甘精胰岛素治疗,研究组行甘精胰岛素联合阿卡波糖治疗.比较两组患者治疗前后的空腹血糖、餐后2 h C肽、糖化血红蛋白、平均血糖波动幅度(MAGE).结果 治疗后...

Clinical value of insulin glargine combined with acarbose in the treatment of elderly patients with type 2 diabetes mellitus

Objective To discuss the clinical value of insulin glargine combined with acarbose in the treatment of elderly patients with type 2 diabetes mellitus. Methods A total of 202 elderly patients with type 2 diabetes mellitus were divided into control group and research group by random numerical table, with 101 cases in each group. The control group was treated with insulin glargine alone, and the research group was treated with insulin glargine and acarbose. Both groups were compared in terms of fasting blood glucose, 2 h postprandial C-peptide, glycosylated hemoglobin, and mean amplitude of glycemic excuisions(MAGE) before and after treatment. Results After treatment, the fasting blood glucose and glycosylated hemoglobin of the two groups were lower than those of this group before treatment, and the fasting blood glucose(5.23±1.86) mmol/L and glycosylated hemoglobin(5.20±1.54)% of the research group were lower than(7.01±2.01) mmol/L and(7.98±2.02)% of the control group. All the differences were statistically significant(P<0.05). After treatment,the 2 h postprandial C-peptide of the two groups were higher than those of this group before treatment, and the postprandial 2 h C-peptide(2.97±0.54) ng/ml of the research group was higher than(2.66±0.55) ng/ml of the control group. All the differences were statistically significant(P<0.05). The MAGE(3.29±1.18) mmol/L of the research group was significantly lower than(4.96±1.32) mmol/L of the control group, and the difference was statistically significant(P<0.05). Conclusion Insulin glargine combined with acarbose in the treatment of elderly patients with type 2 diabetes mellitus can help regulate glucose metabolism and stabilize blood glucose level,which is worthy of promotion.