2型糖尿病患者血胱抑素C与尿微量白蛋白排泄率的关系

目的探讨2型糖尿病患者血胱抑素C与尿微量白蛋白排泄率的关系。方法选取该院内分泌科2011年8月—2012年4月住院的2型糖尿病患者137例进行研究,根据尿微量白蛋白排泄率将其分组。检测血胱抑素C,观察指标间的相互关系。结果无糖尿病肾病组(A组)、早期糖尿病肾病组(B组)和临床糖尿病肾病组(C组)的尿微量白蛋白排泄率分别是(15.24±10.83)mg/24 h,(198.71±63.08)mg/24 h,(1025.36±495.47)mg/24 h;胱抑素C分别是(0.73±0.25)mg/L,(1.43±0.41)mg/L,(2.05±0.59)mg/L。B组、C组与A组比较,尿微量白蛋白排泄率和胱抑素C均有显著性差异(P<0.05)。胱抑素C和尿微量白蛋白排泄率呈正相关(r=0.571,P<0.05)。结论血胱抑素C可做为早期诊断糖尿病肾病的指标。

The Relationship Between Serum Cystatin C and the Urinary Albumin Excretion Rate in Type 2 Diabetic Nephropathy Patients

Objective To observe the levels on serum cystatin C （Cys C）, urinary albumin excretion rate （UAER） in Type 2 Diabetes,and explore the correlation between the two indicators. Methods 137 cases with type 2 diabetes from August 2011 to April 2012 were included .The patients were divided into three groups according to UAER. Cys C were detected. The correlation be- tween the two indicators were observed. Results UAER were 15.24±10.83 mg/24h, 198.71±63.08 mg/24h, 1025.36±495.47 mg/24h in no diabetic nephropathy（DN）group（group A）, early DN group（group B）,clinical DN group（group C）,respectively .Cys C were 0.73±0.25 mg/L, 1.43±0.41 mg/L,2.05±0.59 mg/L, respectively. The UAER and Cys C levels in group B and group C were significantly different from group A（P〈0.05）;Cys C and UAER were positively correlated（r=0.571, P〈0.05 ）. Conclusions Cys C can be used as an indicator for the early diagnosis in type 2 diabetic nephropathy patients.