地佐辛用于腹部肿瘤手术超前镇痛及静脉自控镇痛的研究

目的探讨地佐辛用于腹部肿瘤手术超前镇痛及术后静脉自控镇痛（PCIA）的有效性和安全性。方法选择60例剖腹行结肠癌根治术患者，年龄42～70岁，ASAⅠ-Ⅱ级，随机分为地佐辛纽（D组）和舒芬太尼组（s组），各30例。所有患者选择全身麻醉，缝皮时静脉滴注地佐辛5mg，手术结束时行PCIA，D组：地佐辛0．8mg／kg，S组：舒芬太尼2μg/kg，均生理盐水稀释至100ml。两组患者设置相同镇痛泵参数，监测并记录术后3、6、12、24、48hVAS镇痛评分、48h内按压镇痛泵次数、Ramsay镇静评分及不良反应发生情况。结果两组患者术后各时点VAS评分及48h内按压镇痛泵次数比较差异无统计学意义（P〉0．05），D组患者的Ramsay评分及不良反应发生率均显著低于S组（P〈0．05）。结论地佐辛用于腹部肿瘤手术超前镇痛，效果确切，用于PCIA不良反应发生率低，安全性高，是一种较理想的超前镇痛及PCIA药物。

Dezocine on preemptive analgesia and patient controlled intravenous analgesia following resection of abdominal tumor

Objective To observe the effect of dezoeine on preemptive analgesia and patient controlled intravenous analgesia following resection of abdominal tumor. Methods Sixty patients scheduled for resection of colon cancer, aged 42 - 70, ASA Ⅰ-Ⅱ , were randomly divided into two groups, dezocine group（ group D） and sufentanil group （group S）, with 30 patients in either group. All patientswere given general anesthesia, intravenous injection of dezocine 5 mg when sewing skin and treated with patient controlled intravenous analgesia （PCIA） at the end of operation. PCIA gradients used for group D, group S were deeozine 0. 8 mg/kg and sufentanil 2 txg/kg respectively, which were diluted to 100 ml by adding saline. VAS, Ramsay scores（3 h,6 h, 12 h,24 h,48 h after operation）, pressing times of PCA equipment and adverse effects were recorded and compared. Results There were no significant differences in the VAS scores and pressing times of PCA equipment （ P 〉 0.05 ）. The Ramsay scores and adverse effects of group D were significantly lower than the group S （ P 〈 0.05 ）. Conclusions Dezocine on preemptive analgesia and patient controlled intravenous analgesia following resection of abdominal tumor exhibits good effect of and minor adverse reactions ; which enables a safer and more effective method of analgesia.