未成熟卵体外成熟与体外受精妊娠胚胎移植14 d血清人绒毛膜促性腺激素 β亚单位水平的比较*

背景：相关研究表明,体外受精与胚胎移植治疗妊娠后血清人绒毛膜促性腺激素β亚单位水平对妊娠结局有预测作用,未成熟卵体外成熟治疗妊娠后血清人绒毛膜促性腺激素β亚单位水平对妊娠结局的预测作用不详。 目的：比较不孕症患者体外受精与胚胎移植和未成熟卵体外成熟治疗妊娠后血清人绒毛膜促性腺激素β亚单位水平,探讨血清人绒毛膜促性腺激素β亚单位水平对未成熟卵体外成熟治疗妊娠患者的预测价值。 方法：采用回顾性分析的方法,以在本中心行未成熟卵体外成熟治疗后妊娠实验阳性的42例患者为研究组,同期行体外受精治疗后妊娠实验阳性的66例患者作为对照组,比较两组患者胚胎移植后第14天血清人绒毛膜促性腺激素β亚单位水平。 结果与结论：胚胎移植后14 d,分别在研究组和对照组内,单、双胎妊娠患者血清人绒毛膜促性腺激素β亚单位水平差异均有显著性意义。血清人绒毛膜促性腺激素β亚单位水平≥ 800 U/L时,两组双胎妊娠的发生率均明显增高。提示血清人绒毛膜促性腺激素β亚单位水平对未成熟卵体外成熟治疗后妊娠患者的结局具有预测价值,未成熟卵体外成熟/体外受精妊娠胚胎移植14 d血清人绒毛膜促性腺激素β亚单位水平及其对妊娠结局的预测是相同的。

Comparison of serum human chorionic gonadotropin beta-subunit levels on day 14 after in vitro maturation of immature eggs,in vitro fertilization and embryo transfer

BACKGROUND: Studies have shown that the serum human chorionic gonadotropin β-subunit levels in pregnant women after in vitro fertilization and embryo transfer can predict the pregnancy outcomes. It is unknown whether in the in vitro maturation, it can be a predictive index for the pregnancy outcomes. OBJECTIVE: To evaluate the value of serum human chorionic gonadotropin β-subunit levels in the prediction of pregnancy outcome in women undergoing in vitro maturation, and to compare serum human chorionic gonadotropin β-subunit levels in infertility patients after in vitro maturation and in vitro fertilization and embryo transfer. METHODS: A total of 42 successfully treated pregnant women who received in vitro maturation were enrolled as experiment group; and 66 women who received in vitro fertilization treatment at the same time were enrolled as control group. Retrospective analysis was used to compare the serum human chorionic gonadotropin β-subunit levels in both groups on day 14 after embryo transfer. RESULTS AND CONCLUSION: There was a significant difference in the serum human chorionic gonadotropin β-subunit levels between single pregnancy and gemellary pregnancy in both model group and control group on day 14 after embryo transfer. The incidence of gemellary pregnancy increased significantly in both groups when the serum human chorionic gonadotropin β-subunit level≥ 800 U/L. These findings indicate that human chorionic gonadotropin β-subunit level is a valuable index for the prediction of pregnancy outcome in women received in vitro maturation. The prediction of pregnancy outcomes in women who received in vitro maturation was similar to that in women who received in vitro fertilization and embryo transfer.