婴儿癫痫与TORCH 感染的关系

目的 探讨婴儿癫痫与TORCH感染之间的关系.方法 采用ELISA法对40例婴儿癫痫患儿(癫痫组)和30例同龄健康婴儿(健康对照组)进行血清弓形虫(TOX)、风疹病毒(RV)、巨细胞病毒(CMV)和单纯疱疹病毒(HSV-Ⅰ、HSV-Ⅱ)抗体IgM、IgG水平检测.结果 癫痫组TORCH-IgM抗体阳性7例,其中CMV-IgM阳性7例,TOX-IgM、RV-IgM、HSV-Ⅰ-IgM和HSV-Ⅱ-IgM阳性例数均为0,健康对照组TORCH-IgM抗体阳性例数为0,癫痫组CMV-IgM检出阳性率高于健康对照组(P<0.05),其他TORCH系列抗体的检出阳性率与健康对照组比较差异无统计学意义(Pa>0.05).≤6个月癫痫患儿CMV-IgG抗体阳性24例(82.76%),7~12个月的癫痫患儿CMV-IgG抗体阳性5例(45.45%),≤6个月癫痫患儿CMV-IgG抗体阳性率高于7~12个月患儿(P<0.05).≤6个月癫痫患儿CMV-IgM抗体阳性6例(20.69%),7~12个月的癫痫患儿CMV-IgM抗体阳性1例(9.09%),≤6个月和7~12个月癫痫患儿CMV-IgM抗体检出阳性率比较差异无统计学意义(P>0.05).结论 婴儿癫痫与CMV感染有一定关系.

Relationship between Epilepsy and TORCH Infection in Infants

Objective To explore the relationship between epilepsy and TORCH infection in infants.Methods Serum toxoplasma(TOX),rubella virus(RV),cytomegalovirus(CMV)and herpes simplex virus type-Ⅰ/Ⅱ(HSV-Ⅰ/Ⅱ)immune antibodies(TORCH-IgM/IgG)) were examined by enzyme linked immunosorbent assay in 40 epilepsy infants(epilepsy group)and 30 healthy infants(healthy control group).Results There were 7 patients with positive TORCH-IgM antibody among the 40 epilepsy patients.The number of patients with positive CMV-IgM antibodies were 7 cases and the numbers of patients with positive TOX-IgM,RV-IgM,HSV-Ⅰ-IgM,HSV-Ⅱ-IgM antibodies were 0.The number of healthy infants with positive TORCH-IgM antibody was 0.The positive rate of CMV-IgM immune antibodies in epilepsy group was higher(P<0.05).The positive rate of the other TORCH immune antibodies was not higher than that in healthy control group(Pa>0.05).The positive rate of CMV-IgG(82.76%) in epilepsy patients within 6 months was higher than that in patients of 7-12 months(45.45%)(P<0.05).The positive rate of CMV-IgM in epilepsy patients within 6 months(20.69%) was not higher than that in patients of 7-12 months(9.09%)(P>0.05).Conclusion Epilepsy has a relationship with CMV infection in infants.