|
|||||
|
|
| 康莱特抗小鼠癌症恶病质相关基因表达谱研究 | |
| 引用本文： | 吴煜,杨宇飞,邬冬华,王玉芝,王诤.康莱特抗小鼠癌症恶病质相关基因表达谱研究[J].浙江中西医结合杂志,2004,14(11):664-666. |
| 作者姓名： | 吴煜 杨宇飞 邬冬华 王玉芝 王诤 |
| 作者单位： | 1. 中国中医研究院西苑医院肿瘤科,北京,100091 2. 中国人民解放军军事医学科学院基础所 3. 中国医学科学院基础所 |
| 基金项目： | 国家中医药管理局科研项目 |
| 摘 要： | 目的:寻找中药康莱特抗癌症恶病质的表达差异基因.方法:复制T739小鼠肺腺癌恶病质模型,制备mRNA探针,应用cDNA表达谱芯片,分析差异表达的基因.结果:得到的康莱特治疗组差异表达基因5条,其中1条表达降低,4条表达增高,多数差异表达基因与代谢、免疫相关.结论:运用基因芯片工具和生物信息学方法,能够发现康莱特治疗癌症恶病质相关的差异表达基因,该药对癌症恶病质的作用可能通过调节免疫和代谢过程来实现. |
| 关 键 词： | 小鼠 癌症恶病质 基因表达 康莱特 |
| 修稿时间： | 2004年5月20日 |
Study on the Gene Expression of Kanglaite of Anti-Cancer Cachexia of Mouse |
|
| WU Yu,YANG Yufei,Wu Donghua,et al..Study on the Gene Expression of Kanglaite of Anti-Cancer Cachexia of Mouse[J].Zhejiang Journal of Integrated Traditional Chinese and Western Medicine,2004,14(11):664-666. | |
| Authors: | WU Yu YANG Yufei Wu Donghua |
| Abstract: | Objective: To screen the differential expression genes of Kanglaite Injection in treating cancer cachexia. Methods: mRNA was extracted from the blood cells of T739 animal model of C.C., hybridizated respectively on 20S gene chip. Analysis discuss on differential expression genes was carried out. Results: 5 differential expression genes were obtained. Among these genes, 4 genes were up-regulated and 1 gene was down-regulated. Most of these genes were related with immunity and metabolism of tumor. Conclusion: cDNA microarray for analysis of gene expression patterns is a powerful method to identify associated genes of Kanglaite. |
| Keywords: | mouse KANGLAITE gene expression Cancer Cachexia |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
